Can the Combination of Magnetic Resonance Imaging, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Predict the Mass Origin in Ovarian Masses?

Objective: Evaluate the effectiveness of magnetic resonance imaging (MRI), blood parameters, and tumor markers to determine the role of objective criteria in distinguishing malignant, borderline, and benign masses and to minimize unnecessary surgical interventions by reducing interpretation differences.
Methods: The histopathological and clinical–laboratory results of the patients who underwent surgery for the initial diagnosis and whose ovarian masses were confirmed were retrospectively reviewed. Between groups, age, cancer antigen 125, mean platelet vol- ume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), the presence of ascites, the ovarian-adnexal reporting and data system MRI scores, mass characteristics, and lymphocyte count were compared.
Results: The study comprised a total of 191 patients. These patients were categorized into three groups: Benign (n=113), border- line (n=26), and malignant (n=52). No noteworthy correlation was detected between the unilocular or multilocular nature of solid, cystic, or mixed masses and the rates of NLR, PLR, or MPV. However, a notable correlation was identified between NLR and the presence of acidity (p=0.003). In ovarian cancer patients, there was no significant difference in NLR and MPV between malignant epithelial and malignant sex cord-stromal types (p>0.05), whereas a significant difference emerged in the PLR ratio (p=0.013). Conclusion: In ovarian masses with malignant potential, laboratory parameters such as NLR and PLR can guide the diagnosis pro- cess. In the future, various studies such as the development of different tests, markers, and imaging methods, the use of blood tests such as NLR, PLR, and MPV in cancer diagnosis will be possible. The results of these studies may contribute to the development of new methods for the diagnosis of ovarian cancer and the improvement of treatment protocols.

Manyetik Rezonans Görüntüleme, Nötrofil-Lenfosit Oraný ve Trombosit-Lenfosit Oranýnýn Kombinasyonu, Yumurtalýk Kitlelerindeki Kitle Kökenini Tahmin Edebilir Mi?

Amaç: Malign, borderline ve benign kitlelerin ayrýmýnda objektif kriterlerin rolünü belirlemek ve yorumlama farklýlýklarýný azaltarak gereksiz cerrahi giriþimleri en aza indirmek için MRG, kan parametreleri ve tümör belirteçlerinin etkinliðini deðerlendirmek
Yöntem: Baþlangýç tanýsý için ameliyat edilen ve over kitleleri doðrulanan hastalarýn histopatolojik ve klinik-laboratuvar sonuçlarý retrospektif olarak incelendi. Gruplar arasýnda yaþ, kanser antijeni 125 (CA-125), ortalama trombosit hacmi (MPV), NLR, PLR, asit varlýðý, ORADS MRG skorlarý, kitle özellikleri ve lenfosit sayýsý karþýlaþtýrýldý.
Bulgular: Çalýþmaya toplam 191 hasta dahil edildi. Bu hastalar benign (n=113), borderline (n=26) ve malign (n=52) olmak üzere üç gruba ayrýldý. Solid, kistik veya mikst kitlelerin uniloküler veya multiloküler doðasý ile NLR, PLR veya MPV oranlarý arasýnda kayda deðer bir korelasyon saptanmadý. Bununla birlikte, NLR ile asit varlýðý arasýnda dikkate deðer bir korelasyon tespit edildi (p=0.003). Over kanserli hastalarda malign epitelyal ve malign seks kord-stromal tipler arasýnda NLR ve MPV açýsýndan anlamlý fark yokken (p>0.05), PLR oranýnda anlamlý fark ortaya çýktý (p=0.013).
Sonuç: Malign potansiyeli olan over kitlelerinde NLR ve PLR gibi laboratuvar parametreleri taný sürecinde yol gösterici olabilir. Gelecekte farklý testlerin, belirteçlerin ve görüntüleme yöntemlerinin geliþtirilmesi, NLR, PLR, MPV gibi kan testlerinin kanser teþhisinde kullanýlmasý gibi çeþitli çalýþmalar mümkün olacaktýr. Bu çalýþmalarýn sonuçlarý yumurtalýk kanseri tanýsý için yeni yöntemlerin geliþtirilmesine ve tedavi protokollerinin iyileþtirilmesine katký saðlayabilir. (SETB-2023-08-143)