Assessment of Health-Related Quality of Life in Patients with Ýdiopathic Hirsutism Compared to Patients with Polycystic Ovary Syndrome

Objective: Hirsutism affects 5–15% of women of reproductive age. Health-related quality of life (HQOL) is a multidimensional assessment of well-being that considers the physical, social, and emotional aspects associated with a specific disease. The aim of this study is to evaluate HQOL in patients diagnosed with idiopathic hirsutism (IH) and compare it with patients diagnosed with polycystic ovary syndrome (PCOS).
Methods: This cross-sectional observational study was performed on 183 female individuals, consisting of 51 patients diagnosed with idiopathic hirsutism, 76 patients diagnosed with PCOS, and 56 healthy volunteers. Participants with a history of neuropsychiatric disorders, under 18 and over 45 years of age, during pregnancy and lactation, with any chronic disease that could interfere with diag- nostic laboratory tests, and who had previously been treated for IH or PCOS were excluded from the study. Demographic, anthropo- metric, laboratory, and clinical data on the cases were recorded. The Short Form-36 (SF-36) questionnaire, the Beck Depression Inven- tory (BDI), and the Beck Anxiety Inventory (BAI) were administered in a face-to-face interview by related authors involved in the study. Results: The mean age, level of education, lifestyle, and marital status of all three groups were similar. There were no significant differ- ences in body mass index (BMI) or waist circumference between the groups. Mean modified Ferriman-Gallwey (mFG) scores were similar in the IH and PCOS groups. In the IH patients, the general health and mental health domains of the SF-36 questionnaire scores were sig- nificantly lower than in the control group (p<0.001 and p=0.026, respectively). When the SF-36 questionnaire scores were compared be- tween the IH and PCOS groups, the general health and role emotional domains were significantly lower in the PCOS group (p=0.013 and p<0.001, respectively), and the other domains were similar. All SF-36 questionnaire domains were significantly and negatively correlated with BMI and waist circumference measurements in IH patients. Both BDI and BAI scores were significantly and positively correlated with BMI (r=0.348, p<0.001, and r=0.162, p=0.012, respectively) and waist circumference (r=0.326, p<0.001, and r=0.344, p<0.001, respective- ly). Six out of eight domains of the SF-36 QOL scores were significantly and negatively correlated with the mFG scores.
Conclusion: Patients diagnosed with IH have impaired HQOL, similar to patients diagnosed with PCOS. Improving HQOL should be a goal when deciding on a management approach for hirsutism, which is one of the most common reasons for referral to endo- crinology and dermatology outpatient clinics.

Ýdiopatik Hirsutizmli Hastalarda Saðlýkla Ýliþkili Yaþam Kalitesinin Polikistik Over Sendromlu Hastalara Kýyasla Deðerlendirilmesi

Amaç: Hirsutizm üreme çaðýndaki kadýnlarýn %5-15'ini etkileyen bir problemdir. Saðlýkla iliþkili yaþam kalitesi (HQOL), belirli bir hastalýða baðlý fiziksel, sosyal ve duygusal yönleri dikkate alan çok boyutlu bir refah deðerlendirmesidir. Bu çalýþmanýn amacý idiyopatik hirsutizm (ÝH) tanýsý alan hastalarda HQOL'yi deðerlendirmek ve polikistik over sendromu (PKOS) tanýsý alan hastalarla karþýlaþtýrmaktýr.
Yöntem: Bu kesitsel gözlemsel çalýþma, 51 idiyopatik hirsutizm tanýlý hasta, 76 polikistik over sendromu tanýlý hasta ve 56 saðlýklý gönüllüden oluþan 183 kadýnla gerçekleþtirilmiþtir. Nöropsikiyatrik bozukluk öyküsü olan, 18 yaþ altý ve 45 yaþ üstü, gebelik ve emzirme döneminde olan, tanýsal laboratuvar testlerini etkileyebilecek herhangi bir kronik hastalýðý olan ve daha önce ÝH veya PCOS tedavisi görmüþ olanlar çalýþma dýþý býrakýlmýþtýr. Olgularýn demografik, antropometrik, laboratuvar ve klinik verileri kaydedilmiþtir. Kýsa Form-36 (SF-36) anketi, Beck Depresyon Envanteri (BDI) ve Beck Anksiyete Envanteri (BAI), ilgili yazarlar tarafýndan yüz yüze görüþmelerle katýlýmcýlara uygulandý.
Bulgular: Ortalama yaþ, eðitim düzey, yaþam tarzý ve medeni durum her üç grupta benzerdi. Gruplar arasýnda beden kitle indeksi (BMI) veya bel çevresi açýsýndan anlamlý bir fark bulunmamýþtýr. Ortalama modifiye Ferriman-Gallwey (mFG) skorlarý ÝH ve PKOS gruplarýnda benzerdi. ÝH hastalarýnda, SF-36 yaþam kalitesi skorlarýnýn genel saðlýk ve ruh saðlýðý alanlarý kontrol grubuna göre anlamlý derecede düþüktü (sýrasýyla p<0.001 ve p=0.026). SF 36 yaþam kalitesi skorlarý ÝH ve PKOS gruplarý arasýnda karþýlaþtýrýldýðýnda, genel saðlýk ve duygusal rol alanlarý PKOS grubunda anlamlý derecede düþüktü (sýrasýyla p=0.013 ve p<0.001) ve diðer alanlar benzerdi. Tüm SF-36 yaþam kalitesi alanlarý, ÝH hastalarýnda BMI ve bel çevresi ölçümleri ile anlamlý ve negatif korelasyon göstermiþtir. Hem BDI hem de BAI skorlarý, BMI (sýrasýyla r=0.348, p<0.001 ve r=0.162, p=0.012) ve bel çevresi (sýrasýyla r=0.326, p<0.001 ve r=0.344, p<0.001) ile anlamlý ve pozitif korelasyon göstermiþtir. SF-36 yaþam kalitesi skorlarýnýn sekiz alanýndan altýsý mFG skorlarý ile anlamlý ve negatif korelasyon göstermiþtir.
Sonuç: ÝH tanýlý hastalarýn saðlýkla iliþkili yaþam kalite düzeyleri, PKOS tanýlý hastalara benzer þekilde düþüktür. Endokrinoloji ve dermatoloji polikliniklerine baþvurularýn sýk nedenlerinden biri olan hirsutizm için hasta yönetiminde hedeflerden biri de HQOL'yi iyileþtirmek olmalýdýr. (SETB-2023-08-147)