The Effect of Local Tranexamic Acid Administration on Blood Loss and Transfusion in Total Knee Arthroplasty: A Retrospective Study

Objectives: The standard surgical method for primary gonarthrosis in advanced stages is total knee arthroplasty (TKA), despite the risk of bleeding that requires transfusion. Blood transfusions are potentially dangerous. The aim of this study was to determine whether there is a statistical difference in the amount of bleeding and the need for transfusion between patients who received and did not receive perioperative local tranexamic acid in TKA.
Methods: The hospital data system was used to access the data of patients who underwent TKA in our clinic between January 2015 and January 2022 with a diagnosis of gonarthrosis. Patients who underwent TKA and had gonarthrosis as the primary diagnosis were included in the study. They were separated into two groups: A control group (Group C) and a group that received perioperative local tranexamic acid (Group LTXA). The amount of bleeding was compared by taking into account patients’ hemogram follow-ups, the amount of blood from their drains, and their transfusion needs during the postoperative period.
Results: The findings demonstrated that TKA patients who received local tranexamic acid administration experienced a significant decrease in perioperative blood loss and needed lesser transfusions.
Conclusion: The findings of our investigation are consistent with other studies and are in favor of the usage of TXA in TKA. To validate our findings and establish the ideal TXA dosage and administration method in TKA, additional research is required.

Total Diz Artroplastisinde Lokal Traneksamik Asit Uygulamasýnýn Kan Kaybý ve Transfüzyon Üzerine Etkisi: Retrospektif Bir Çalýþma

Amaç: Ýleri evre primer gonartroz için standart cerrahi yöntem, transfüzyon gerektiren kanama riskine raðmen total diz arthroplastisidir (TKA). Kan transfüzyonu potansiyel olarak tehlikelidir. Bu çalýþmanýn amacý, perioperatif lokal traneksamik asit alan ve almayan hastalar arasýnda kanama miktarýnda ve transfüzyon ihtiyacýnda istatistiksel bir fark olup olmadýðýný belirlemektir.
Yöntem: Hastane veritabaný Ocak 2015 ile Ocak 2022 tarihleri arasýnda gonartroz nedeni ile total diz arthroplastisi yapýlan hastalarýn verilerine eriþmek için kullanýlmýþtýr. Hastalar iki gruba ayrýldý: kontrol grubu (Grup C) ve peroperatif lokal tranexamic asit uygulanan grup. (Grup LTXA). Kanama miktarý, hastalarýn hemogram takipleri, cerrahi drenden gelen kan miktarýný ve ameliyat sonrasý dönemde transfüzyon ihtiyaçlarýný dikkate alarak karþýlaþtýrýldý.
Bulgular: Lokal traneksamik asit uygulamasýnýn total diz artroplastisin de hastalarýnýn perioperatif kan kaybýnýn önemli ölçüde azaldýðýný ve daha az transfüzyona ihtiyaç duyduðunu gösterdi.
Sonuç: Araþtýrmamýzýn bulgularý diðer çalýþmalarla uyumludur ve TKA'da TXA kullanýmýný destekler. Bulgularýmýzý doðrulamak ve TKA'da ideal TXA dozajý ve uygulama yöntemi oluþturmak için ek araþtýrmalar gereklidir. (SETB-2023-04-067)