Liken planus hastalarýnda dislipidemi: Vaka-kontrol çalýþmasý

Amaç: Liken planus (LP) deri,mukoz membranlar,saçlý deri ve týrnaklarý etkileyen kronik inflamatuar bir hastalýktýr.Daha önce yapýlan çalýþmalarda diabetes mellitus ve dislipidemi prevelansý LP hastalarýnda daha yüksek saptanmýþtýr.Fakat bu çalýþmalarýn çoðu retrospektif ve geriye dönük lipid düþürücü ilaç kullanan hastalarýn dahil edildiði veritabaný taramasý þeklinde idi.Bu çalýþma LP ve dislipidemi iliþkisini incelemeyi hedefleyen prospektif bir vaka-kontrol çalýþmasýdýr.
Yöntem: Bu çalýþma 49 LP hastasý ve 99 saðlýklý kontrol üzerinde yapýlmýþtýr.Tüm hastalar klinik ve histopatolojik incelemeye,kontrol grubu ise klinik incelemeye tabi tutulmuþtur.Analiz edilen deðiþkenler yaþ,cinsiyet,sigara kullanýmý,hipertansiyon,lipid profilleri ve açlýk kan glikozudur.
Bulgular: Hasta grubunda serum trigliserit,total kolesterol ve LDL kolesterol düzeyleri daha yüksekti.Fakat,istatiksel olarak anlamlý fark saptanmadý.Hasta ve kontrol gruplarýnýn yaþ ortalamalarý,cinsiyet,sigara içiciliði ve hipertansiyon oranlarýnda anlamlý fark saptanmadý.
Sonuçlar: Bu prospektif vaka-kontrol çalýþmasý, ortalama lipit deðerlerinin LP hastalarýnda daha yüksek olduðunu ortaya koymuþtur.Ýstatiksel olarak anlamlý olmasa da; klinisyenler bu iliþkiden haberdar olmalý ve bu hastalarý dislipidemi için taramayý düþünmelidir.

Dyslipidemia in Lichen Planus: A Case-control Study

Objectives: Lichen planus (LP) is a chronic inflammatory disease that affects the skin, mucous membranes, scalp and nails. It has been reported that diabetes mellitus and dyslipidemia prevalence were higher in patients with LP. However, most of these reports were retrospective, database search, which included patients who were on lipid-lowering drugs. This study aims to conduct a prospective case-control study to investigate the association between LP and dyslipidemia.
Methods: This study was conducted on 49 patients with LP (mucosal or cutaneous) and 99 healthy controls. All patients were subjected to clinical and histological examination, whereas controls were subjected to clinical examination. The variables analyzed were age, sex, tobacco consumption, hypertension, lipid profiles and fasting blood glucose.
Results: Serum levels of triglycerides, total cholesterol and LDL cholesterol were higher in patients with LP. However, there was no significant difference between patients with LP and controls. No significant differences between LP patients and controls were observed with the average age, sex, tobacco consumption and hypertension.
Conclusion: This prospective case-control study demonstrated that dyslipidemia was more common among patients with LP. Physicians should be aware of this association and consider screening them for dyslipidemia.