Nefrotik sendromla gelen sekonder sifiliz

Sifiliz, T. pallidum adý verilen spiroket etkenli cinsel yolla bulaþan bir hastalýktýr. Gösterdiði klinik tablolara baðlý olarak ‘büyük simülatör’ olarak da tanýnmaktadýr. Sifiliz ve renal hastalýklar arasýndaki iliþki yüzyýldan uzun bir süredir bilinmektedir. Proteinüri en yaygýn görülen klinik göstergedir. Sifilizle iliþkili olarak membranöz glomerülonefrit, hýzlý ilerleyen glomerülonefrit, ekstrakapiller oluþumlu ya da oluþumsuz diffüz endokapiller glomerülonefrit ve minimal deðiþim glomerülonefrit tanýmlanmýþtýr. Kesin taný böbrek biyopsisiyle konulmaktadýr. VDRL ve TPHA pozitif olup nefrotik sendromla baþvuran ve yapýlan böbrek biyopsisinde evre 1 membranöz glomerülopati saptanan bir olgu sunuyoruz.

The nephrotic syndrome with secondary syphilis

Syphilis is a sexually transmitted disease which is caused by a spirochete called T. pallidum. It is known as ‘the great simulator’, owing to its range of clinical presentations. The relationship between syphilis and renal disease has been recognized for more than 100 years. Proteinuria is the most common clinical manifestation. Membranous glomerulonephritis, rapidly progressive glomerulonephritis, diffuse endocapillary glomerulonephritis with or without extracapillary formation or minimal change glomerulonephritis have been described in association with syphilis. The definitive diagnosis is confirmed by renal biopsy. We report a VDRL and TPHA positive patient who presented with nephrotic syndrome whose renal biopsy demonstrated stage one membraneous glomerulopathy.