Med Bull Sisli Etfal Hosp. 2023; 57(1): 25-32 | DOI: 10.14744/SEMB.2022.66742

The effect of High-Dose Vitamin C Treatment for Acute Respiratory Failure Due to Coronavirus Disease Pneumonia on Mortality and Length of Intensive Care Stay: A Retrospective Cohort Study

Nurcan Coskun, Mustafa Altinay, Hacer Sebnem Turk, Nebia Peker, Serkan Islamoglu, Ayse Surhan Cinar, Melis Turkel Ozkan
Department of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Türkiye

Objectives: In our study, we aimed to determine the effect of vitamin C on short-term mortality and length of intensive care unit (ICU) stay in patients with coronavirus disease (COVID-19) followed up in the ICU.
Methods: The patients who received and those who did not receive the high-dose intravenous vitamin C protocol were assigned to the treatment and control groups, respectively. The primary study findings in both groups were length of ICU stay and shortterm mortality, while the secondary findings were vasopressor and invasive mechanical ventilation requirements and change in sequential organ failure assessment score from the 0 to the 96th hour.
Results: Thirty-eight patients were included in the treatment group and 40 were included in the control group. The mortality rates were 44% and 60% in the treatment and control groups, respectively; however, the difference between the groups was not statistically significant (p>0.05). The median length of ICU stay in both groups was 10 days (p>0.05). No significant differences in the invasive mechanical ventilation and vasopressor requirements were found between the groups (p>0.05).
Conclusion: Consequently, the high-dose vitamin C therapy in the patients with acute respiratory failure due to COVID-19 pneumonia did not reduce the length of ICU stay, mortality, and invasive mechanical ventilation and vasopressor reqirements.

Keywords: Ascorbic acid, coronavirus disease, intensive care, respiratory distress syndrome, sepsis

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Koroavirüs Hastalýðý Pnömonisine Baðlý Akut Solunum Yetmezliðinde Yüksek Doz C Vitamini Tedavisinin Mortalite ve Yoðun Bakýmda Kalýþ Süresine Etkisi: Retrospektif Kohort Çalýþmasý

Nurcan Coskun, Mustafa Altinay, Hacer Sebnem Turk, Nebia Peker, Serkan Islamoglu, Ayse Surhan Cinar, Melis Turkel Ozkan
Türkiye Saðlýk Bilimleri Üniversitesi, Þiþli Hamidiye Etfal Eðitim ve Araþtýrma Hastanesi, Anesteziyoloji ve Reanimasyon Anabilim Dalý, Ýstanbul

Amaç: Çalýþmamýzda yoðun bakým ünitesinde (YBÜ) takip edilen koronavirüs hastalýðý (COVID-19) hastalarýnda C vitamininin kýsa dönem mortalite ve yoðun bakým ünitesinde kalýþ süresine etkisini belirlemeyi amaçladýk.
Metod: Yüksek doz intravenöz C vitamini protokolü alan ve almayan hastalar sýrasýyla tedavi ve kontrol gruplarýna ayrýldý. Her iki grupta da birincil çalýþma bulgularý YBÜ kalýþ süresi ve kýsa dönem mortalite iken, ikincil bulgular vazopresör ve invaziv mekanik ventilasyon gereksinimleri ve Sequential Organ Failure Assessment Skorunun 0'dan 96. saate deðiþimi idi.
Bulgular: Tedavi grubuna 38, kontrol grubuna 40 hasta dahil edildi. Tedavi ve kontrol gruplarýnda mortalite oranlarý sýrasýyla %44 ve %60 idi; ancak gruplar arasýndaki fark istatistiksel olarak anlamlý deðildi (p<0.05). Her iki grupta da median yoðun bakým kalýþ süresi 10 gündü (p<0.05). Gruplar arasýnda invaziv mekanik ventilasyon ve vazopresör gereksinimlerinde anlamlý fark bulunmadý (p<0.05).
Sonuç: Sonuç olarak, COVID-19 pnömonisine baðlý akut solunum yetmezliði olan hastalarda yüksek doz C vitamini tedavisi, yoðun bakýmda kalýþ süresini, mortaliteyi, invaziv mekanik ventilasyon ve vazopresör gereksinimlerini azaltmadý. (SETB-2022-11-244)

Anahtar Kelimeler: Askorbik Asit, Koronavirüs Hastalýðý, Yoðun Bakým, Solunum Yetmezliði Sendromu; Sepsis

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