Impact of Variant Histology on Clinical and Pathological Outcomes in Patients with the Upper Urinary Tract Urothelial Carcinoma

Objectives: The objective of the study was to determine the effect of variant histology on pathological outcomes and survival in patients operated for the upper urinary tract urothelial carcinoma (UTUC).
Methods: Data of 128 patients who were operated for UTUC between 2001 and 2019 were retrospectively analyzed. Patients with pure urothelial carcinoma and patients with variant histology were compared in terms of demographics, pathological outcomes, and survival.
Results: The mean age of the patients was 65±11 years, female to male ratio was 30/98 and median follow-up period was 26.5 (1–176) months. Variant histology was detected in 14.8% of patients. Variant histology was found to be associated with surgical margin positivity, lymph node metastasis, presence of lymphovascular invasion, high tumor stage and grade (p=0.001, p=0.012, p=0.001, p=0.002, and p=0.009, respectively). Three-year cancer-specific and overall survival rates were 79.6% and 77.3%, respectively. There was no statistically significant relationship between variant histology with cancer-specific and overall survival (p=0.514 and p=0.515, respectively).
Conclusion: Variant histology of UTUC was found to be associated with locally advanced disease, but its effect on survival could not be demonstrated.

Impact of variant histology on clinical and pathological outcomes in patients with upper urinary tract urothelial carcinoma

Amaç: Varyant histolojinin üst üriner sistem ürotelyal karsinomu nedeni ile ameliyat olan hastalarýn patolojik ve sað kalým sonuçlarýn üzerindeki etkisini saptamak.
Yöntem: 2001-2019 yýllarý arasýnda tek merkezde üst üriner sistem ürotelyal karsinomu nedeni ile ameliyat olan 128 hastanýn verileri geriye dönük olarak incelendi. Saf ürotelyal karsinom hastalarý ve varyant histoloji olanlar demografik özellikler, patolojik sonuçlar ve sað kalým parametreleri açýsýndan birbiri ile karþýlaþtýrýldý.
Bulgular: Ortalama hasta yaþý 65±11yýl olarak saptandý. Kadýn erkek oraný 30/98 olarak, medyan takip süresi ise 26,5 (1-176) ay olarak belirlendi. Hatalarýn 14,8% inde varyant histoloji saptandý. Varyant histoloji cerrahi sýnýr pozitifliði, lenf nod metastazý, lenfovasküler invazyon varlýðý, yüksek tümör evre ve derecesi ile iliþkili bulundu (p=0.001, p=0.012, p=0.001, p=0.002, p=0.009, sýrasýyla). 3 yýllýk kanser spesifik ve genel sað kalým oraný sýrasýyla 79,6% ve 77,3% olarak saptandý. Varyant histoloji ile kanser spesifik sað kalým ve genel sað kalým arasýnda istatistiksel anlamlý bir iliþki belirlenemedi. (p=0.514, p=0.515, sýrasýyla).
Sonuç: Üst üriner sistem ürotelyal karsinomunda varyant histoloji lokal ileri hastalýk ile iliþki iken, sað kalým üzerinde bir etkisi gösterilemedi. (SETB-2021-06-175)