Comparison of the effects of propofol and sevoflurane on liver-renal function tests and recovery characteristics in long lasting surgeries

Objective: The aim of this study was to compare the effects of propofol and sevoflurane anaesthesia on renal and hepatic function tests and recovery characteristics in long lasting surgeries.
Study design: After the approval by the Medical Ethic Committee of the hospital, 36 patients in ASA l-II physical status were randomized two groups. Anaesthesia was induced with propofol and atracuriurn and maintained with propofol infusi¬on (4-8 mg/kg/h) in Group P and with sevoflurane (2-3%) in Group S. Blood urea nitrogen, serum creatinin, AST, ALT levels were determined preoperatively, every 2 hours peroperatively, 30. min and 24 th hours postoperatively. As recovery characteristics time until eye opening, response to verba! commands, orientation-cooperation time were evaluated.
Results: Anaesthesia time was 349.7 minutes in Group P and 355.5 minutes in Group S. Laboratory values were similar between groups. There was not any significant difference between preoperative and postoperative values. Time until eye opening and response to verbal commands were shorter in Group P than Group S, but the difference was not significant. Orientation-cooperation time was statistically longer in Group S than Group P.
Conclusion: Propofol or sevoflurane has not any significant effect on liver or renal function tests, but recovery was faster with propofol in patients undergoing long lasting surgeries.

Uzun süreli operasyonlarda propofol ve sevofluranýn karaciðer- böbrek fonksiyon testleri ve derlenme üzerine etkilerinin karþýlaþtýrýlmasý

Amaç: Çalýþmamýzda, uzun süreli operasyonlarda propofol ile sevofluranm karaciðer; böbrek fonksiyon testleri ve derlenme üzerine etkilerinin karþýlaþtýrýlmasý amaçlanmýþtýr.
Gereç ve yöntem: Hastane Etik Kurul izniyle ASA /-//, 36 olgu rasgele 2 gruba ayrýldý. Propofol ve atraküryumla indüksiyonu takiben, anestezi idamesinde Grup P’de propofol infüz- yonu(4-8 mg/kg/saat), Grup S’de sevofluran(%2-3) kullanýl¬dý. Lire, kreatinin, AST ve ALT preoperatif, peroperatif 2 saat arayla, postoperatif 30. dk ve 24. saatlerde tespit edildi. Der¬lenme; gözlerini açýna, sözel uyarýya yanýt, oryantasyon-ko- operasyoýý zamanlarý ile deðerlendirildi.
Bulgular: Anestezi süreleri; Grup P’de ortalama 349.7 dk, Grup S’de 355.5 dk idi. Laboratuar bulgularý gruplar arasýn¬da benzerdi. Postoperatuar dönemde preoperatuar döneme göre anlamlý fark saptanmadý. Gözlerini açma ve sözel uyarýya yanýt süreleri Grup P‘de Grup S’ye göre kýsa olmakla birlikte, aradaki fark anlamlý, bulunmadý. Oryantasyon-kooperasyorý zamanlan Grup S’de anlamlý olarak uzundu.
Sonuç: Propofol veya sevofluran He uzun süreli operasyonlarda karaciðer ve böbrek fonksiyon testlerinde anlamlý deðiþiklikler olmamýþ, ancak derlenme propofol ile daha hýzlý olmuþtur.