The relationship of hs-CRP with regulation of hypertension in patients who have both Type 2 diabetes mellitus and hypertension

Objective: In different studies, it was determined that diabetes mellitus and hypertension can increase hs-CRP levels. In this study, we aim to compare the levels of hs-CRP between 2 groups with controlled or uncontrolled hypertension in patients who have both type 2 diabetes mellitus and hypertension.
Material and Method: We enrolled 64 female and 65 male, total 129 patient, into the study who admitted to our diabetes polyclinic between 2010 May and 2010 September. Patient’s sociodemographic properties, detailed histories, drug usage, anthropometric measures, physical examination findings and laboratuary results were investigated. Situations that affect CRP levels were excluded from the study. In this study, level of significance was considered to be p<0.05.
Results: In the study, 49.6% (n=64) of patients were female, and 50.4% (n=65) were male. Those who have regulated blood pressure was 65 (50.4%) and who have not regulated blood pressure was 64 (49.6%) people. Mean body mass index was 30.17±5.30 kg/m2. The mean duration of diabetes was 6.69±4.57 years, the mean duration of hypertension was 6.38±4.41 years. Those who have regulated hypertension, mean body mass index was 29.81±5.44, who have not regulated hypertension was 30.53±5.18. There was no statistically significant difference between the groups in terms of gender (p>0.05). There was no statistically significant difference between the groups in terms of HbA1c, total cholesterol, HDL- cholesterol, LDL- cholesterol, VLDL- cholesterol, triglyceride, TSH, fasting blood glucose, postprandial blood glucose, AST, ALT, proteinuria ve creatinine. Also, there was no statistically significant difference between the groups in terms of hs-CRP.
Conclucion: Patients with type 2 diabetes mellitus who have hypertension, it was determined that controlling the blood pressure did not constitute a significant difference in hs-CRP levels.

Hipertansif Tip 2 Diabetes Mellitus’lu hastalarda tansiyon regülasyonunun yüksek duyarlýklý C-reaktif protein (hs-CRP) ile iliþkisi

Amaç: Diabet ve hipertansiyonun, deðiþik çalýþmalarla hs-CRP’yi artýrdýðý saptanmýþtýr. Biz bu çalýþ- mayla tip 2 diabetli hipertansif olgularda tansiyonu kontrol altýnda olan ve olmayan 2 grup arasýnda hs-CRP düzeylerini karþýlaþtýrmayý hedefledik.
Gereç ve Yöntem: Çalýþmamýza 2010 Mayýs-2010 Eylül tarihleri arasýnda diabet polikliniðimize baþvuran 64’ü kadýn, 65’i erkek olmak üzere toplam 129 olgu alýndý. Çalýþmaya alýnan olgularýn, sosyodemografik özellikleri, detaylý öyküleri, antropometrik ölçümleri, fizik muayene bulgularý, laboratuvar tetkikleri incelendi. CRP deðerini etkileyen durumlarý olan olgular çalýþma dýþý tutuldu. Çalýþmamýzda anlamlýlýk düzeyi p<0.05 olarak kabul edildi.
Bulgular: Olgularýn %49.6’sý (n=64) kadýn, %50.4’ü (n=65) erkek, yaþ ortalamasý 55.81±8.15 idi. Tansiyonu regüle olanlar 65 (%50.4), regüle olmayanlar 64(%49.6) kiþiydi. Beden kitle indeksleri (kg/m2 ) ortalamasý 30.17±5.30 idi. Diabet sürelerinin ortalamasý 6.69±4.57 yýl, hipertansiyon süreleri de ortalama 6.38±4.41 yýl idi. Tansiyonu regüle olan olgularýn beden kitle indeksi ortalamalarý 29.81±5.44, regüle olmayanlarýn ise 30.53±5.18 idi. Gruplarda cinsiyetler açýsýndan istatistiksel olarak anlamlý farklýlýk saptanmadý (p>0.05). Laboratuar bulgularýndan hs-CRP, HbA1c, total kolesterol, HDL, LDL, VLDL, trigliserid, TSH, açlýk kan glukozu, tokluk kan glukozu, AST, ALT, proteinüri ve kreatinin ölçümlerinde tansiyonu regüle olan ve olmayanlar arasýnda anlamlý farklýlýk görülmedi (p>0.05).
Sonuç: Tip 2 diabetes mellitus tanýlý hipertansiyonu olan olgularda tansiyonu kontrol altýna almanýn hs-CRP düzeyi açýsýndan anlamlý farklýlýk oluþturmadýðý saptanmýþtýr.