Non-HDL cholesterol, total cholesterol/HDL cholesterol and LDL-cholesterol levels in patients with acute ischemic stroke

Objective: Ischemic stroke is defined as acute neurological disorder according to cerebral vascular damage and reduced blood flow to a particular region of the brain. Ischemic stroke is a major cause of morbidity and mortality and placed 3rd among the causes of death. About 80% of all strokes depend on ischemic cause. Atherosclerotic plaque rupture or addition of a thrombus on plaque is the most common cause of ischemic stroke. Atherosclerosis is associated with the level of blood lipids from the first stages of the formation process. In our study, we aimed to investigate non-HDL, total cholesterol / HDL-cholesterol and LDL-cholesterol levels in patients with acute ischemic stroke.
Methods: This study was performed in 52 patients who were admitted at Ankara Numune Hospital for Education and Investigation, Division of Neurology between December 2009- May 2010 with a diagnosis of acute ischemic stroke in the first 24 hours and 48 healthy individuals matched for age and gender, who was admitted at the hospital during the same period. Total cholesterol, triglycerides and HDL cholesterol levels were measured by DXC 800 autoanalyzer (Beckmann-Coulter, USA). LDL cholesterol, total cholesterol / HDL-cholesterol and non-HDL cholesterol levels were calculated according to the formulas.
Results: Patient group had significantly lower HDL-C levels than the control group (p=0.009), whereas the triglyceride and total cholesterol / HDL-C levels were significantly higher (p=0.013, p=0.018). Total cholesterol, LDL cholesterol and non-HDL cholesterol levels did not differ significantly between groups. There were significant correlations between non-HDL-cholesterol levels and triglycerides, total cholesterol, LDL cholesterol (respectively r=0.468, r=0.964, r=0.851) (respectively p<0.001, p<0.001, p<0.001), and there was not a statistically significant correlation between non –HDL -cholesterol and HDL cholesterol.
Conclusion: Dyslipidemia process plays a role in the pathogenesis of atherosclerosis which is an important risk factor for acute ischemic stroke. In our study, in terms of total cholesterol, non-HDL cholesterol and LDL cholesterol levels, there was not a significant difference but triglyceride, total cholesterol / HDL-cholesterol and HDL cholesterol levels were found to be significantly different.

Akut iskemik inmeli hastalarda non-HDL, total kolesterol, HDL kolesterol ve LDL-kolesterol düzeyleri

Giriþ ve Amaç: Ýskemik inme, vasküler hasara baðlý olarak beynin belirli bir bölgesine serebral kan akýmýnýn azalmasý ile birlikte akut geliþen nörolojik bozukluk olarak tanýmlanmaktadýr. Ýskemik inme önemli bir morbidite ve mortalite nedeni olup ölüm nedenleri arasýnda 3.sýrada yer almaktadýr. Tüm inmelerin yaklaþýk %80’i iskemik nedenlere baðlýdýr. Ýskemik inmelerin en sýk nedeni ise aterosklerotik plak rüptürü veya plak üzerine trombüs eklenmesidir. Ateroskleroz, ilk oluþum evrelerinden itibaren kan lipid düzeyi ile iliþkili bir süreçtir. Biz çalýþmamýzda akut iskemik inmeli hastalarda non-HDL, Total Kolesterol, HDL Kolesterol ve LDLKolesterol düzeylerini incelemeyi hedefledik.
Gereç ve Yöntemler: Çalýþmaya Aralýk 2009 - Mayýs 2010 tarihleri arasýnda Ankara Numune Eðitim ve Araþtýrma Hastanesi Nöroloji Servisine ilk 24 saatlik akut dönemde baþvuran ve akut iskemik inme tanýsý alan 52 olgu ile 42 saðlýklý birey katýldý. Hasta ve kontrol grubunun total kolesterol, trigliserit ve HDL kolesterol düzeyleri DXC-800 otoanalizöründe (Beckman-Coulter, ABD) ölçüldü. LDL kolesterol, Total kolesterol/HDL kolesterol ve non-HDL kolesterol düzeyleri ise formüllerle hesaplandý.
Bulgular: Hasta grubunda kontrol grubuna göre HDL-K seviyeleri anlamlý olarak düþük (p=0.009) iken, trigliserit ve total kolesterol/HDL seviyeleri ise anlamlý olarak yüksekti (p=0.013,p=0.018). Total kolesterol, LDL ve non-HDL kolesterol seviyelerinde gruplar arasýnda istatistiksel olarak anlamlý farklýlýk yoktu. Non-HDL kolesterol düzeyi ile trigliserit, total kolesterol ve LDL kolesterol arasýnda anlamlý korelasyon bulunurken (sýrasýyla r=0.468, r=0.964, r=0.851) (sýrasýyla p<0.001, p<0.001, p<0.001), HDL kolesterol ile anlamlý korelasyon yoktu.
Sonuç: Akut iskemik inmede önemli risk faktörü olan aterosklerozun patogenezinde rol oynayan dislipidemik süreçte, total kolesterol, non-HDL kolesterol ve LDL kolesterol düzeyleri açýsýndan anlamlý bir farklýlýk bulunmadýðý fakat trigliserit ve total kolesterol/HDL kolesterol ve HDL kolesterol düzeyinin anlamlý bir farklýlýk bulunduðu sonucuna varýlmýþtýr.