The preliminary results of radio-chemotherapy in locally advanced gastric and pancreas cancer

Between February 2000 and November 2003 we treated 22 stomach and 10 pancreas cancer patients with definitive, adjuvant or palliative radiation and concurrent chemotherapy in the Department of Radiotherapy, Akdeniz University. Median age of the gastric cancer patients was 53 (27-69); 15 were men and 7 were women. Median age of the patients with pancreas cancer was 60 (48-78); 6 were men and 4 were women. The gastric and pancreas cancer patients received external beam radiation with linear accelerator to a median total dose of4729 (4140-5400) cGy and 4896 (4140-5400) cGy, respectively. The gastric and pancreas cancer patients received 5FU+leucovarin and 5FU, respectively. Median follow- up of the gastric cancer patients was 20,6 months (5-46). Of the 22 patients with gastric cancer, fourteen patients (64%) died due to local-regional recurrence + metastasis, 4 patients (18%) were alive with local-regional recurrence, and the other 4 (18%) were alive free of disease. Median follow-up of the patients with pancreas cancer was 14,1 months (6-22). Of the 10 patients with pancreas cancer, 8 (80%) died due to local-regional recurrence, and 2 (20%) died due to local- regional recurrence + metastasis. A multidisciplinary treatment approach for pancreas and stomach cancer, where modern radiotherapy techniques are used to minimize normal tissue complications was established in our institute, and the preliminary results were presented in this study.

Lokal-bölgesel ileri evre mide ve pankreas kanserli hastalarda radyokemoterapi önsonuçlarý

Þubat 2000 ile Kasým 2003 tarihleri arasýnda, Akdeniz Üniversitesi Týp Fakültesi Radyasyon Onkolojisi Kliniði’nde 22 mide ve 10 pankreas kanserli hastaya définitif, post-operatif adjuvan veya palyatif radyoterapi (RT) ve eþ zamanlý kemoterapi (KT) uygulandý. Mide kanserli hastalarýn 15’i erkek, 7’si kadýndý ve ortalama yaylarý 53 (27-69)’tir. Pankreas kanserli hastalarýn ise; 4‘ii kadýn ve 6’sý erkekti. Hastalarýn ortalama yayý 60 (46-78) idi. Mide kanserli hastalara 180 cGylgüm‘fraksiyon dozu ile tümör ve tümör yataðýna ortanca total 4729 (4500-5580) cGy, pankreas kanserli hastalara ise 4896 (4140-5400) cGy eksternal RT lineer hýzlandýrýcý cihazý kullanýlarak uygulandý. Mide kanserli hastalara ey zamanlý 5- FU ve 5-FU+LV ve pankreas kanserli hastalara da 5-FU ke- moterapisi uygulandý. Mide kanserli 22 hastanýn ortalama iz¬lem süresi 20.6 ay (5-46 ay) dir. Mide kanserli hastalarýn takibinde 22 hastadan 14’ü (%64) hastalýða (lokal bölgesel nüks ± uzak metastaz) baðlý kaybedildi, 4 hasta (%18) hastalýklý (lokal bölgesel nüks ± uzak metastaz) ile hayatta ve 4 ‘ ii (%18) de hastalýksýz olarak hayattadýr. Pankreas kanserli 10 hastanýn ise ortalama izlem süreleri 14.1 ay (6-22 ay) olup takiplerinde hastalardan 8’i (%80) hastalýða (lokal bölgesel hastalýk ± uzak metastaz) baðlý kaybedilirken, 2’si (%20) de lokal nüks ve metastatik hastalýkla yayanýmý sürdürmektedir. Kuruntumuzda pankreas ve mide kanserli hastalar iyin normal doku yan etkilerini en aza indiren modern radyoterapi tekniklerinin kullanýldýðý multidisipliner tedavi yaklayýmý yerleþmiþtir ve ön sonuçlar bu çalýþmada verilmiþtir.