Comparison of body mass index and lipid levels between obese and normal weighted hypothyroid patients

Objective: In hypothyroidic patients obesity and hyperlipidemia is more often. In this study hypothroid patients followed by Haseki Hospital lipid polyclinic evaluated and hyperlipidemia-obesity relation investigated.
Material and Method: Files of 37 hypothyroidic patients followed up by lipid polyclinic of Haseki Hospital between 2003-2006 years are evaluated retrospectively. Patients divided into two groups as obese (case) and nonobese (control) according to their body mass indexes (BMI) (≥30=obese) at the time they refer. Age, sex, BMI, glucose, TSH, total-cholesterol, LDL, HDL, triglyceride values of patients evaluated.
Results: 19 were obese (case group), 18 were nonobese (control group) from 37 patients with hypothyroidism admitted to our study. Case group had 1 male, 18 female, control group had 6 male, 12 female patients. In case group, HDL was lower (p<0.01) and glucose was higher (p<0.01) than control group. Triglycerides of case group was higher than control group, but this difference wasn’t significant (p=0.31). There wasn’t difference between groups in the levels of total and LDL-cholesterol.
Conclusion: We evaluated hypothroidic patients by dividing them to obese and nonobese groups according to their BMI. Total and LDL cholesterol levels of groups showed no significant difference. Trigliceryde and glucose levels of obese group was high and HDL-cholesterol was low. During therapies of hypothyroidic patients, hyperlipidemia have to be investigated and also when beginning of an antihyperlipidemic treatment thyroid hormones have to be evaluated.

Obez ve normal kilolu hipotiroidi hastalarýnýn beden kitle indeksi ve lipid deðerlerinin karþýlaþtýrýlmasý

Amaç: Hipotiroidi hastalarýnda obezite ve beraberinde hiperlipidemi görülmektedir. Bu çalýþmada Haseki Eðt. Arþ. Hastanesi lipit polikliniðinden takip edilen hipotirodi hastalarýnýn laboratuar verileri deðerlendirilerek hipotiroidik hastalarda obezite ile lipit deðerleri iliþkisi araþtýrýldý.
Gereç ve Yöntem: Haseki Eðt. Arþ. Hastanesi lipit polikliniðinde 2003-2006 yýllarýnda takip edilen 37 hipotiroidi hastasýnýn dosyasý retrospektif olarak incelendi ve hastalar, baþvuru sýrasýndaki vücut kitle indeksleri (VKÝ) (≥30=obez) dikkate alýnarak obez (vaka) ve nonobez (kontrol) olarak 2 gruba ayrýldý. Çalýþmada hastalarýn yaþ, cinsiyet, VKÝ, glukoz, TSH, total kolesterol, LDL, HDL, trigliserit deðerleri dikkate alýndý.
Bulgular: Çalýþmaya alýnan 37 hipotiroidi hastasýndan 19’u obez (vaka grubu), 18’i nonobez (kontrol grubu) olarak deðerlendirildi. Vaka grubu 1 erkek, 18 kadýn, kontrol grubu ise 6 erkek, 12 kadýn hastadan oluþtu. Vaka grubunun HDL deðerleri anlamlý olarak düþük saptandý (p<0.01). Glukoz deðerleri de anlamlý olarak yüksek saptandý (p<0.01). Vaka grubunun trigliserit deðerleri kontrol grubuna kýyasla
yüksek olmakla birlikte istatistiksel anlamlý bir fark yoktu (p=0.31). Gruplar arasýnda LDL ve total kolesterol açýsýndan anlamlý bir farklýlýk saptanmadý.
Sonuç: Hipotiroidili hastalarda obezite sýk görülmekte olup, bu grupta hiperlipidemi ve glukoz intoleransýna da daha sýk rastlanmaktadýr. Yaptýðýmýz çalýþmada VKÝ’lerine göre obez ve nonobez olarak ikiye ayrýlan hipotiroidi hastalarýnýn total kolesterol ve LDL deðerleri arasýnda anlamlý bir fark saptanmadý. Obez grubun trigliserit ve glukoz deðerleri yüksek, HDL deðerleri düþük saptandý. Hipotiroidi hastalarýnýn tedavisi sýrasýnda hiperlipidemi gözden kaçýrýlmamalý ayný zamanda tek baþýna hiperlipidemisi olan hastalarda tedavi öncesi tiroid hormonlarý görülmelidir.