Relationship Between Fasting Total Levels and Ischemic Heart Disease and Proteinuria in NIDDM Patients

OBJECTIVE: To assess the value of homocysteine as a potential candidate to explain the relationship between type II DM patients with elevated total homocysteine concentration with nephropathy and cardiovascular mortality and morbidity.
MATERIAL AND METHOD: 44 type II DM patients were included in the study. The patients were seperated into three groups and the homocysteine, creatinine, trygliceride, cholesterol, LDL, HDL, Hb A1C levels were compared between the groups.
RESULT: The homocysteine level differences between the groups were statistically significant (p<0.05); between group I and group II, homocysteine levels were higher in group II with proteinuric patients; between group I and group III, homocysteine levels were higher in patients with ischemic heart disease in group III; comparison between group II which had patients with ischemic heart disease and proteinuria had higher levels of homocysteine than group III. The other parameters did not show statistically significant differences between the groups (p>0.05).
CONCLUSION: Homocysteine levels were higher in the NIDDM patients with ischemic heart disease and/or proteinuria. It is concluded that doctors diagnosing and following up diabetic patients and trying to lower the risk of cardiovascular mortality and morbidity should take into consideration hyperhomocysteinemia, which is a treatable and independent risk factor.

NIDDM’LÝ hastalarda açlýk total homosistein düzeyi ile Ýskemik Kalp Hastalýðý ve proteinüri arasýndaki iliþki

AMAÇ: Yükselmiþ total homosistein konsantrasyonu ile nefropatili TÝP II DM’li hastalarda artmýþ kardiyovasküler morbidité ve mortalité arasýndaki iliþkiyi açýklamak için homosistein‘in potansiyel bir aday olup olmadýðým göstermeyi amaçladýk.
MATERYAL VE METOD: 44 TÝP II DM hasta çalýþmaya alýndý.Hastalar 3 gruba ayrýlarak, gruplar arasýnda homosistein, kreatinin,trigliserid, kolesterol, LDL, HDL, HbAIc arasýndaki iliþki karþýlaþtýrýldý.
BULGULAR: Her üç grubun homosistein deðerleri karþýlaþtýrýldýðýnda aralarýnda istatistiksel bir farklýlýk saptanmýþ olup (p0.05)
SONUÇ: Iskemik kalp hastalýðý ve/veya proteinürisi olan NIDDM’li hastalarda homosistein düzeyi yüksek saptanmýþtýr. Diabetik hasta teþhis, tedavi ve takip eden kardiyovasküler morbidité ve mortalité riskini düþürmeyi amaçlayan hekimlerin tedavi edilebilir baðýmsýz bir risk faktörü olan hiperlýomosistein’ eminin farkýnda olmalarý gerektiðini tespit etmeyi amaçladýk.