Maternal thyroid functions in pre-eclampsia

Objective: In this study, we aimed to evaluate the relationship between pre-eclampsia and thyroid profile.
Material and Method: In this case control study, serum concentrations of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) were prospectively measured in fifty preeclamptic patients compared with thirty normotensive pregnant controls before labor. Both groups were composed of various pregnant females in the third trimester. Two groups were also compared with regard to obstetrical outcomes.
Results: Levels of TSH, FT3 and FT4 showed no significant difference between the pre-eclamptic group and normotensive controls. Regarding obstetrical outcomes; the difference was found to be significant for gestational age when studying labor and birth-weight between two groups. Preeclamptic patients delivered at earlier gestation and had lower infant birth-weights compared with normotensive controls. Also, we did not find any statistically significant correlation between thyroid function and birth-weight in both groups.
Conclusion: Our findings suggest that thyroid function does not change in pre-eclampsia. Therefore, the identification of thyroid hormone in pregnancy can not help obstetricians to predict the occurrence of pre-eclampsia.

Preeklampside maternal tiroid fonksiyonlarý

Amaç: Çalýþmamýzda, preeklampsi ile tiroid hormonlarý arasýndaki iliþkiyi incelemeyi amaçladýk. Gereç ve Yöntem: Bu çalýþmada, serum tiroid stimule edici hormon (TSH), serbest triiodotironin (FT3) ve serbest tiroksin düzeyleri (FT4) 50 preeklamptik gebe ve 30 normotansif gebede doðumdan önce prospektif olarak ölçüldü. Her iki grup da 3. trimesterdeki gebelerden oluþmaktaydý. Gruplar tiroid hormonlarý ve obstetrik sonuçlar açýsýndan karþýlaþtýrýldý.
Bulgular: Serum TSH, FT3 ve FT4 düzeyleri açýsýndan iki grup arasýnda anlamlý bir fark saptanmadý. Ancak, doðum haftasý ve doðum aðýrlýðý açýsýndan her iki grup arasýndaki fark istatistiksel olarak anlamlýydý. Normotansif kontroller ile karþýlaþtýrýldýðýnda, preeklamptik hastalar daha erken gebelik haftasýnda doðurdular ve bu grupta, yenidoðan doðum aðýrlýðý daha düþüktü. Diðer yandan, iki grupta da, tiroid fonksiyonlarý ve doðum aðýrlýðý arasýnda anlamlý korelasyon saptanmadý.
Sonuç: Bulgularýmýz, tiroid fonksiyonlarýnýn preeklampside deðiþmediðini göstermektedir. Bu nedenle gebelikte tiroid hormonlarýnýn preeklampsiyi ön görmede kadýn doðum hekimlerine yardýmcý olamayacaðý kanýsýndayýz.