Cerebral atrophy and mini mental state in multipl sclerosis

Objective: In this study bifrontal and bicaudate indexes of the patients with MS were compared with normal values and by doing this was aimed to investigate primarily if there was atrophy in MS,if these alterations had relations with the patient age, gender, duration of the disease clinical functional state (score of EDSS), MMS, by using MRI.
Study design: 34 patients with MS were included in the study.Poser‘s classification and clinical typing were madeln cranial MRI bifrontal and bicaudate indexes were calculated.The demographical properties of the patients, the scores of EDSS, the score of MMS were recorded.
Results: The group of patients was formed by 18 women (mean age 31,7229.266) and 16 men (mean age 33,750±10.516).When compared with the normal values,in patients bicaudate indexes (16,378±3,482) were not very different than the normal control values (mean 15,9±2,8). In patients group bifrontal indexes mean were found prominently high (35,6876,607) than the normal correlation values (31,1 ±3,7)(p<0,001). A significant correlation between the duration of the disease and bifrontal index values was established (404;p<0,0109). Gender, smoking didn’t cause any difference in index values.
Conclusion: As conclusion it was considered that in patients with MS cerebral atrophy was one of the important findings which should be fallowed and for this purpose the measuring of bifrontal and bicaudate indexes were easy methods that could be used.

Multiple sklerozda serebral atrofi ve mini mental durum

Amaç: Bu çalýþmada MS tanýsý almýþ hastalarda kraniel MR da hifrontal indeks ve bikaudat indeksi normal bireylerdeki deðerlerle karþýlaþtýrarak öncelikle MS de serebral atrofi olup olmadýðýný, bu deðiþikliklerin hastanýn yaþ ve cinsiyeti, hastalýðýn süresi, klinik ve fonksionel durum (EDSS Skoru), MMS ile iliþkisi olup olmadýðýnýn araþtýrýlmasý amaçlanmýþtýr.
Gereç-Yöntem: 34 MS hastasý çalýþmaya dahil edildi. Poser sýnýflamasý ve klinik tiplendirme yapýldý. Kraniel MRI da bifrontal ve bikaudat indeksler hesaplandý. Hastalarýn demografik özellikleri, EDSS skorlarý, MMS skoru kaydedildi.
Bulgular: Hasta grubu 18 kadýn (yaþ ort. 31,722±9,266), 16 erkek (yaþ ort.33,750+10f 16) hastadan oluþtu. Normal deðerle karþýlaþtýrýldýðýnda bikaudat indeks hastalarda (165378±3,482) normal kontrol deðerlerinde (ort. 15,9±2,8) belirgin farklýlýk göstermedi. Bifrontal indeksler ise hasta grunda (ort.35,687+6,607) normal deðerlerden (31,1+3,7) belirgin olarak yüksek bulundu (p<0,001). Hastalýk süresi ile bifrontal indeks deðerleri arasýnda anlamlý korelasyon saptandý (404; p<0,019). Cinsiyet, sigara kullanýmý indeks deðerlerinde farklýlýk yaratmadý.
Sonuç: Multiple Sklerozlu hastalarda serebral atrofinin izlenmesi gereken önemli bulgulardan biri olduðu ve bu amaçla bifrontal ve bikaudat indeks ölçümlerinin kolay bir yöntem olarak kullanýlabileceði düþünüldü.