Study Of Von Willebrand Factor in Hypertensive And Normotensive Diabetic Patients

OBJECT: Von Willebrand Factor levels, which is an indicator of endothelial damage, were studied in diabetic patients.
MATERIAL AND METHOD: A total of 79 patients, 19 men and 60 women were followed up by the Sisli Etfal Hospital Diabetes Clinic were includud in the study. The patient were divided in five groups depending on the duration and regulation of diabetes and the presence of hypertension and the results were compared statistically.
RESULTS: In the hypertensive groups, von Willebrand factor levels were significantly higher (p<0.05) than the normotensive groups. There were no stasistically significant relationship between von Willebrand factor levels and the duration or the regulation of diabetes (p>0.05 ).
CONCLUSiON: In the development of diabetic angiopathy, disturbance of glucose level regulation does not have a major role by itself, but it is concluded that accompanying risk factor (hypertension) causes endothelial damage.

Hipertansif ve Normotansif Diabetik Hastalarda Von Willebrand Faktör Düzeylerinin Ýncelenmesi

AMAÇ: Diabetik hastalarda eýýdotel hasarýnýn göstergelerinden birisi olan von Willebrarýd Faktör düzeylerini inciledik.
MATERYAL VE METOD: Çalýþmaya Þiþli Etfal Eðitim ve Araþtýrma Hastanesi Diabet polikliniðinde takip edilen 19 erkek, 60 kadýn toplam 79 hasta alýndý. Hastalar, diabet süresi, diabet regülasyoýuý ve hipertansiyon olup olmamasýna göre 5 ayrý gruba ayrýldý ve sonuçlar istatistiki açýdan karþýlaþtýrýldý.
BULGULAR: Hipertansif olan gruplarda von Willebrand düzeyleri anlamlý þekilde yüksek bulunurken (P<0.05), von Willebrand Faktör düzeyleri ile diabet yaþý ve diabetiýý regüle olup olmamasý arasýnda anlamlý bir iliþki bulunamadý. (P>0.05). SONUÇ: Diabet anjiopatinin geliþiminde bozuk glikoz regiilasyonunun tek baþýna önemli bir rol oynamadýðýný, beraberindeki risk faktörünün (hipertansiyon) eýýdotel hasarýna daha fazla yol açtýðýný düþündürmektedir.