Our Results External Radiothrapy in Oligodendrogliomas

PURPOSE: Oligodendrogliomas is of 1-5% of primary intracranial tumors in adults. Adjuvant radiotherapy is suggestedfollowing maximal surgical resection. This study retrospectively evaluates the oligodendroglioma cases who applied to our clinic in 10 years.
MATERIALAND METHOD: 615 cases with intracranial tumors applied to our clinic between 1985-1999. 14 patients had oligodendrogliomas (2.27%). 6 werefemale and 8 were male. (Female!Male: 314). The most common age range was endroglioma-astrocytoma. in ali patients the tumor had supratentorial localization. The tumor was in the frontal lobe in 5, parietal lobe in 4, parietooxypital lobes in 3, temporal lobe in 1, and frontotemporoparietal lobes in 1 patient. According to Karnofsky Performance Scale (KPS); 6 patients were at 90%, 5 were at 70%, 1 was at 50%, 1 was at 30%, 1 was at 10% status. The mostfrequent surgery was subtotal resection (7 patients-50%). 4 patients were at stage 2a, 7 at stage 2b, 3 at stage 4. 12 patinets ad total cranial, 2 had partial cranial radiotherapy, 11 patients had postoperative radiotherapy, 3 inoperable patients had radiotherapy following biopsy. 3 patients had palliative total cranial radiotherapy of 30 Gy! 10 fraction due to low KPS, 9 had total cranium+boost radiotherapy of total 46-60 Gy/23-30 fraction, 2 had partial cranial radiotherapy of 50 Gy/25 fraction.
RESULTS: 5 of our patients currently survive disease-free, 9 are excitus, 6 had no disease-free survival, and 8 had an average disease free survival of 26 months. The mean survival is 19.7 mounths (3-55 months). lf the patient‘s condition is appropriate, partial cranial radiotherapy yields the longest disease-free and total survival times. (The mean disease-free survival is 38.5 months and the total survival is 41 months).

Oligodendrogliomalarda Eksternal Radyoterapi Sonuçlarýmýz

AMAÇ: Oligodendrogliomalar, yetiþkinlerde primer intrakranial tümörlerin% 1-5‘ ini oluþturur. Maksimal cerrahi rezeksiyon arkasýndan adjuvan radyoterapi önerilir. Bu çalýþmada kliniðimize 1 O yýl içinde baþvuran oligodendroðlýo‘!}(l vakalarý retrospektif olarak irdelenmiþtir.
GEREÇ VE YONTEM: Kliniðimizde 1985-1999 yýllarý arasýnda intrakranial tümörlü 615 vaka baþvurmuþtur. Bunlardan 14 hasta oligodendrogliomadýr. (%2.27)Kadýn hasta 6. erkek hasta 8 idi. ( Kadýn/erkek: 3/4) En sýk görülen yeþ grubu 40-50 yaþ idi. ( 14-72 yaþ) 9 hasta grade 2, 2 hasta grade 3, 2 hasta grade 4 oligodendroglioma, 1 hasta grade2 mixed oligodendroglioma - astrositoma. Hastalarýn tümünde tümör, supratentorial yerleþimliydi. Frontal fob 5, parietal lop 4, parietooksipital fob/ar, 3 temporal lobi, frontotemporoparietal fob 1 hasta‘ da yerleþim yeridir. Karnofsky Performans Skalasýna göre; 6 hasta KPS % 90.5 hasta KPS % 70,1 hasta KPS % 50,1 hasta KPS % 30,J hasta KPS %10 durumda idi. En sýk uygulanan cerrahi þekli; subtotal rezeksiyon olmuþtur. (7 hasta-%50) 4 hasta evre 2a, 7 hasta evre 2b, 3 hasta evre 4 idi. 12 lfastaya total kranial, 2 hastaya parsiyel kranial radyoterapi uygulanmýþtýr. 11 hastaya postoperatif radyoterapi, 3 inoperabl hastaya biyopsi sonrasý radyoterapi uygulanmýþtýr, 3 hasta KPS düþüklüðü nedeni ile total kranium 30 Gy, 1 O fraksiyonda palyatif, 9 hastaya total kranium + boost toplam 46-60 Gy! 23-30 fraksiyonda, 2 hastaya parsiyel kranium 50 Gy/25 fraksiyonda eksternal radyoterapi uygulanmýþtýr.
SONUÇ: Halen hastalarýmýzdan 5‘ i hastalýksýz yaþamaktadýr, 9 hasta eksitus olmuþtur. 6 hastada hastalýksýz yaþam olmamýþ, 8 hastada ise ortalama hastalýksýz yaþam süresi 26 ay olmuþtur. Ortalama yaþam süresi 19,7 aydýr. (3-55 ay) Eðer hasta uygun þartlarda ise parsiyel kranial radyoterapi ile en uzun hastalýksýz ve toplam sað kalým süreleri elde edilmektedir. ( Hastalýksaz sürvi ortalama 38,5 ay, toplam sað kalým süresi ortalama 41 aydýr.)