Acute-Phase Stroke Outcome and Lipids

Objectives: The aim of the study is to investigate the relationship of lipid subgroups with short-term mortality in acute stroke (AS).
Methods: This retrospective study included 698 patients with AS who presented within 24 h of symptom onset. A hemogram from peripheral venous blood samples was taken at admission. Total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), TC/HDL-C rate, and TG/HDL-C rate were recorded. Duration of follow-up was defined as 30 days.
Results: 64 out of 698 patients died during the follow-up period. The mean TG, TG/HDL-C, and TC/HDL-C levels were significantly lower in the mortality group than the survival group. In the receiver operating characteristic (ROC) analysis, the cutoff values and area under the curve of the TG, TG/HDL-C, TC, and TC/HDL-C levels for short-term stroke mortality are as follows ([100.2 mg/dL, 0.648]; [2.52, 0.650]; [170.50 mg/dL, 0.598]; and [4.32, 0.640], respectively). In the Cox regression model, only TG and TG/HDL-C, according to their ROC cutoff values, were independent variables as short-term mortality predictors (TG ≤100.2 mg/dL, HR: 2.413, 95% CI: 1.345–4.327, P: 0.004); (TG/HDL ≤2.56, HR: 2.720, 95% CI: 1.389–5.359, P: 0.003, respectively).
Conclusion: Dyslipidemia is a well-known as a risk factor of stroke. However, this study focused on the estimation that lower TG and TG/HDL-C levels at the time of hospital admission might be predictors of short-term mortality within a month of AS attack, which is a different subject from long term risk factors of stroke. Serum TG level may be a better indicator for mortality in the acute hypercatabolic trauma such as stroke.

Akut Dönem Ýnme Gidiþati Ve Lipidler

Amaç: Lipid subgruplarý ile akut inme kýsa dönem mortalite iliþkisini araþtýrmak amaçlanmýþtýr.
Methods: Bu çalýþma 24 saat içinde semptomlarý baþlayan 698 akut inme hastasýný içeren retrospektif bir çalýþmadýr. Periferik venöz kan hemogram örnekleri hastalarýn kabulünde alýndý. Total kolesterol (TK), trigliserit (TG), high-density lipoprotein (HDL-K), low-density lipoprotein (LDL-K), TK/HDL-K oraný ve TG/HDL-K oraný kaydedildi. Ýzlem süresi 30 gün olarak tanýmlandý.
Bulgular: Ýzlem periyodu süresinde 698 hastanýn 64’ü öldü. Ortalama TG, TG/HDL-K oraný ve TK/HDL-K oraný mortalite grubunda yaþam grubuna göre anlamlý derecede düþüktü. “the receiver operating characteristic (ROC)” analizinde kýsa dönem inme mortalitesi için TG, TG/HDL-K, TK, and TK/HDL-K’ nin kestirim deðerleri ve eðim altý alan deðerleri hesaplandý [sýrasýyla (100.2 mg/dL, 0.648); (2.52, 0.650); (170.50 mg/dL, 0.598); (4.32, 0.640)]. Cox regresyon modelinde ROC kestirim deðerlerine göre TG and TG/HDL-K kýsa dönem mortalite için öngördürücü baðýmsýz deðiþkenlerdi (sýrasýyla, TG ≤100.2 mg/dL, HR: 2.413, 95% CI: 1.345-4.327, p: 0.004); (TG/HDL ≤2.56, HR: 2.720, 95% CI: 1.389-5.359).
Sonuçlar: Dislipidemi inme için iyi bilinen bir risk faktörüdür. Ancak bu çalýþmada akut inme ataðýnýn kýsa dönem mortalitesinde düþük TG and TG/HDL-K’nin bir örgördürücü olabileceði konusu üzerinde odaklanýlmýþtýr, bu durum ise risk faktörü yönetiminden farklýdýr. Serum trigliserit seviyesi inme gibi akut hiperkatabolik durumlarda mortalite için daha iyi bir öngördürücü olabilir. (SETB-2020-05-083)