The importance of prediabetes and therapeutic approach

Prediabetes is the intermediate period between normoglycemia and type 2 diabetes mellitus. Fasting plasma glucose concentration between 100 and 125 mg/dl (Impaired fasting glucose) or second hour plasma glucose concentration of oral glucose tolerance test between 140-199 mg/dl (Impaired glucose tolerance) is termed as prediabetes. Also, HbA1c level between 5.7-6.4% has been accepted as prediabetes according to the recommendations of ADA in 2010. Every year 5 to 10% of prediabetic patients progress into type 2 diabetes mellitus. As associated with dislipidemia, hypertension and obesity, prediabetes is an important risk factor for developing cardiovascular diseases. So, early diagnosis and treatment for prediabetes may interfere in preventing type 2 diabetes development.

Prediyabetin önemi ve tedavi yaklaþýmý

Prediyabet, tip 2 diyabet ve normoglisemi arasýndaki ara dönem olarak tanýmlanabilir. Açlýk plazma glukozunun 100-125 mg/dl olmasý (Bozulmuþ açlýk glukozu) ya da 75 gr oral glukoz tolerans testinde 2 saat plazma glukozunun 140-199 mg/dl olmasý (Bozulmuþ glukoz toleransý) prediyabet olarak adlandýrýlýr. ADA 2010 önerilerine göre HbA1c düzeyinin %5.7–6.4 arasýnda olmasý da prediyabet kabul edilmiþtir. Prediyabetiklerin her yýl %5-10’u aþikar tip 2 diyabete dönüþmektedir. Dislipidemi, hipertansiyon ve obezite ile iliþkili olan prediyabet, kardiyovasküler hastalýk açýsýndan ciddi risk faktörüdür. Bu nedenle, prediyabetin erken tanýnmasý ve tedavisi ile tip 2 diyabet geliþimine müdahale edilebilir.