Does Pulmonary Hamartoma Increase the Risk of Lung Cancer? Outcomes of 38 Pulmonary Hamartoma Cases

Objectives: Hamartomas are common benign tumors of the lung. Rarely, lung cancer coincidence may occur at the time of diagnosis or in the follow-up period.
Methods: Between 2016 and 2019, 38 patients who underwent a surgical procedure and diagnosed with lung hamartoma were retrospectively evaluated regarding clinicopathological features. Cases were analyzed according to age, sex, radiological findings, localization of nodules, surgical methods, and the coincidence of lung cancer.
Results: The mean age was 50.2±11.1 (range 28–76 years). There were 23 male (60.5%) and 15 female (39.5%) patients. Mean size was 2.7±1.8 (range 0.8–10 cm). In 28 patients, hamartoma was <3 cm in diameter (73.6%). Eighteen hamartomas were localized in the upper lobe (47.4%). Only 6 cases (15.8%) were localized at the central part of the lung. Multiple nodules were reported in 10 cases (26.3%). In 4 cases (10.5%), lung carcinoma and hamartoma were seen together at the time of diagnosis. Video-assisted thoracoscopic surgery (VATS) has been performed in 29 cases (76.3%). As a surgical method, enucleation was performed in 4 cases (10.5%), wedge resection in 28 cases (73.7%), and lobectomy in 6 cases (15.8%). No post-operative mortality appeared in the early follow-up.
Conclusion: Pulmonary hamartomas are usually present as solitary pulmonary nodules with benign radiological findings. VATS wedge resection is a method that can be used safely in diagnosis and treatment. Hamartomas may be associated with lung cancer at the time of diagnosis or follow-up, so it should be kept in mind that a different nodule seen in patients diagnosed with hamartoma may be associated with lung cancer.

Pulmoner Hamartom Akciðer Kanseri Riskini Artýrýr mý? 38 Pulmoner Hamartom Olgusunun Sonuçlarý

Amaç: Hamartomlar akciðerin sýk görülen iyi huylu tümörleridir. Nadiren, teþhis sýrasýnda veya takip sýrasýnda akciðer kanseri görülebilir.
Yöntem: 2016-2019 yýllarý arasýnda ameliyat edilen ve akciðer hamartomu tanýsý alan 38 hasta klinikopatolojik özellikleri açýsýndan retrospektif olarak incelendi. Olgular yaþ, cinsiyet, radyolojik bulgular, nodüllerin lokalizasyonu, cerrahi yöntemler ve akciðer kanseri insidansýna göre analiz edildi.
Sonuçlar: Ortalama yaþ 50.2 ± 11.1 (daðýlým 28-76) idi. 23 erkek (%60.5) ve 15 kadýn (%39.5) hasta vardý. Ortalama çap 2.7 ± 1.8 (daðýlým 0.8-10 cm) idi. 28 hastada hamartom çapý <3 cm (%73,6) idi. 18 olguda (%47.4) hamartom lokalizasyonu üst lobdaydý. 6 olgu (%15.8) hamartom santral yerleþimliydi. 10 olguda (%26.3) multiple nodül tespit edildi. Taný anýnda 4 olguda (%10.5) akciðer kanseri ve hamartom birlikte görüldü. 29 olguya (%76.3) video yardýmlý torakoskopik cerrahi (VATS) uygulandý. Cerrahi yöntem olarak, 4 olguda (%10.5) enükleasyon, 28 olguda (%73.7) wedge rezeksiyonu ve 6 olguda (% 15.8) lobektomi yapýldý. Ameliyat sonrasý erken dönem takiplerde mortalite görülmedi.
Sonuç: Pulmoner hamartomlar sýklýkla benign radyolojik bulgularý olan soliter pulmoner nodüller olarak görülür. VATS wedge rezeksiyon, taný ve tedavide güvenle kullanýlabilecek bir yöntemdir. Hamartomlar taný veya takip sýrasýnda akciðer kanseri ile birliktelik gösterebilir, bu nedenle hamartom teþhisi konan hastalarda görülen farklý bir nodülün akciðer kanseri ile iliþkili olabileceði akýlda tutulmalýdýr. (SETB-2020-06-097)