Endothelin-1 Levels at the Essential Hypertansion and Atherosclerosis

OBJECTIVE: The aim of this study was to determine the levels of endothelin-1 (ET-1) which is indicator for disfunction of endoethelin at the normotensive patients who have essential hypertension and atherosclerosis and to compare with the levels of ET-1 in healty people.

STUDY DESIGN: The levels of plasma ET-1 is determined at the 45 patients who have a essential hypertansion and 15 patients who have normotensive atherosclerotic coronary heart disease and 15 healthy people with the met­hod of radio immunassay (RİA).

RESULTS: It is determined that when the intensity of hypertension and damage of the organ are increased at the patients who have essential hypertension, the fevels of ET-1 increased significantly too. There was a positive correlation between the levels of ET-1 and age,duration of hyper­tension, body mass index, sistolic and diastolic blood pressure, smoke, the levels of plasma glucose, total cholestem/ and negative correlation with the levels of HDL choleste­rol. The levels of plasma ET-1 was high significantly at the normotensive patients who have atherosclerotic coronary heart disease.

CONCLUSION: ET-1 wlýich is an indicator of disfunction of endothel plays an important role in the etiopatogenes of both disease and the development of complications.

Esansiyel Hipertansiyon ve Aterosklerozda Endotelin-1 Düzeyleri

AMAÇ: Bu çalýşma esansiyel hipertansiyonlu ve aterosklerozu olan normotansif hasralarda endotel disfonksiyonunun bir göstergesi olan plazma endotelin-1 (ET-1) düzeylerinin saptanmasý ve saðlýklý kişilerin düzeyleri ile karşýlaştýrýlmasý amacý ile yapýlmýştýr.
MATERYAL VE METOD: 45 esansiyel hipertansiyonlu ve 15 normotansif atemskleroýik kormýer kalp hastasý ve 15 saðlýklý korýtml gruhýýnuýý plazma ET-1 düzeyleri radio immünassay (RİA) metodu ile saptandý.
BULGULAR: Esansiyel hipertansiyonlu hastalarda, hipetansiyonun şiddeti ve organ hasarý arttýkça ET-1 düzeylerininde anlamlý bir şekilde arttýğý saptandý. ET-1 düzeyleri ile yaş, hipertansiyonun süresi, vücut kitle indeksi, sistolojik ve diastolik kan basýnçlarý, sigara kullanýmý, plazma glikoz, total kolesterol, LDL kolesteml düzeyleri ile pozitif korelasyon, HDL kolesterol düzeyleri ile negatif korelasyon saptandý. Aterosklerotik koroner kalp hastalýğý olan normotansif hastalarda da plazma ET-1 düzeyleri anlamlý derecede yüksek bulundu.
SONUÇ: Endotel disfonksiyonunun bir göstergesi olan ET-1, her iki hastalýðýn etyopatogenezinde ve komplikasyonlarýn gelişiminde önemli rol oynamaktadýr.