Comparison of three antibacterial regimens in the treatment of tonsillopharyngitis due to beta-hemolytic strepto cocci in children

Objective: Comparison of the efficacy of oral penicillin, clarithromycin and azithromycin in the treatment of patients with tonsillopharyngitis due to group Afihemolytic streptococcus (GABHS) in throat cultures.
Patients and methods: The study included 60 patients diagnosed with acute tonsillopharyngitis whose throat cultures revealed GABHS. These patients were divided randomly and equally into three groups. First group was treated with oral penicillin and the second group with clarithromycin for 10 days. The third group was treated with azithromycin for 3 days. The efficacy of treatment was evaluated by the presence or absence of growth in throat cultures done 3-7 days after the completion of the therapy.
Results: Bacterial eradication was achieved in 19 patients in the penicillin (95 %) and in all of the patients (100 %) in clarithromycin and azithoromycin groups. There were no statistically significant differences between the groups in regard to bacterial eradication rate. (P > 0.05).
Conclusion: It is concluded that azithromycin and clarithromycin can also be effectively used as well as conventional oral penicillin in the bacterial eradication and treatment of GABHS tonsillopharyngitis.

Çocuklarda beta-hemolitik streptokoklara baðlý tonsillofarenjit tedavisinde üç farklý ilaç rejiminin etkinliðinin karþýlaþtýrýlmasý

Amaç: Boðaz kültüründe A grubu beta-hemolitik streptokok (AGBHS) üreyen hastalarda oral penisilin V, klaritromisin ve azitromisin tedavilerinin etkinliklerini karþýlaþtýrýldý.
Gereç ve Yöntemler: Çalýþmaya akut tonsillofarenjit tanýsý konulan ve boðaz kültürlerinde A grubu beta-hemolitik strep¬tokok üreyen 60 hasta alýndý.Hastalar iiç eþit gruba ayrýldý. Birinci gruba on giin süreyle penisilin V, ikinci gruba 10 gün süreyle klaritromisin ve üçüncü gruba iiç gün süreyle azitro¬misin verildi. Tedavinin etkinliði antibiyotik tedavisinin biti¬minden 3-7 gün sonra alýnan boðaz kültürlerinde üreme olup olmamasýna göre deðerlendirildi.
Bulgular: Her iiç grupta orofarenks AGBHS kiiltiirü pozitif olan 20’þer hastadan antibiyotik tedavisi sonrasýnda penisilin grubunun 19’unda (%95), klaritromisin ve azitromisin grubu¬nun tamamýnda (%100) bakteri eradikasyonu saptandý. Bak¬teri eradikasyunu bakýmýndan gruplar arasýnda istatistiksel olarak anlamlý fark yoktu (p>0.05).
Sonuç: Bu bulgularla AGBHS tonsillofarenjitinin tedavisinde ve bakteri eradikasyonunda konvansiyonel penisilin tedavisi¬nin yaný sýra azitromisin ve klaritromisinin de etkili bir þekil¬de kullanýlabileceði sonucuna varýldý.