Relation between pruritus and plasma histamine level in cases with chronic hemodialysis

OBJECTIVE: This study is planned to investigate the relation between pruritus and plasma histamine levels in cases with end stage renal failure who is treated with hemodialysis.
STUDY DESIGN: 14 patients who have treated with hemodialysis (6 females and 8 males; aged between 20-68 years) were included to our study. As for the control group 14 healthy people selected (6 females, 8 males aged between 24-65 years).
Patients who have treated with hemodialysis were separated 2 groups who have pruritus(Group A) and who haven't (Group B). The levels of plasma histamine determined with the method of RIA.
RESULTS: There was no statistically significant changes found between Group A and Group B. Also no significant changes was found between patients who have treated with hemodialysis and control group.
CONCLUSION: These results may show us there is no relation between pruritus and plasma histamin levels at patients who have treated with hemodialysis.

Kronik Hemodiyaliz Hastalarýnda Pruritus ve Plazma Histamin Düzeyi Arasýndaki Ýlişki

AMAÇ: Bu çalýşma, hemodiyalize giren son dönem kronik renal yetersizlikli hastalarda, pruritus ve plazma histamin düzeyi arasýndaki ilişkiyi araştýrmak amacýyla planlandý.
MATERYAL VE METOD: Çalýşmamýza yaşlarý 20-68 arasýnda değişen 6 kadýn, 8 erkek olmak üzere toplam 14 hemodiyaliz hastasý ve yaşlarý 24-65 arasýnda değişen 6 kadýn, 8 erkek olmak üzere sağlýklý 14 kontrol hastasý alýn­dý. Hemodiyalize giren hastalar pruritusu olanlar (n: 8) ve pruritusu olmayanlar (n: 6) olmak üzere iki gruba ayrýldý. Bu hastalarda RIA metodu ile plazma histamin düzeylerine bakýldý.
BULGULAR-SONUÇ: Pruritusu olan ve olmayan hemodiyaliz hastalarý arasýnda plazma histamin düzeyi açýsýn­dan istatistiksel olarak anlamlý bir sonuç bulunamadý. Bu hastalar ile kontrol grubu arasýnda da anlamlý bir sonuç saptanmadý.
Sonuç olarak yaptýğýmýz bu çalýşmada, hemodiyaliz hastalarýnda pruritus ile plazma histamin düzeyi arasýnda istatistiksel olarak anlamlý bir ilişki olmadýğý gösterildi.