Med Bull Sisli Etfal Hosp. 2002; 36(4): 32-35

The relationship between severe ischemia and endogenous sex hormone levels in postmenopausal women with coronary artery disease

Fatih Borlu¹, Ali Özgür Öztürk¹, Kerim Küçükler¹, Songül Peker¹, Nihat Özer^2
1Third Department of Pediatrics, Þiþli Etfal Training and Research Hospital, Istanbul, Turkey
²Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul

Objective: This study prospectively evaluated the association between endogenous serum sex hormone levels and the degree of myocardial ischemia in postmenopausal women with established as clinical and laboratory coronary heart disease.
Material and Methods: 94 women with coronary artery disease and 46 healthy women were included in the study.These groups were enrolled as clinic,biochemical,angiographic,exercise test and SPECT findings. The two groups were seperated as normal,mild- moderate and severe ischemia according to the results of the tests.Serum estradiol and free testosteron levels were measured in the last two groups and compared.
Results: The estradiol levels were significantly lower than other groups in the severe ischemic group(p<(),01). Free testosteron levels were significantly higher than other groups in the severe ischemic group(p=(),()2).No difference was found in total testosteron levels between all groups

Keywords: Coronary artery disease, postmenopausal women, endogenous sex hormones.

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Koroner arter hastalýklý postmenopozal kadýnlarda endojen seks hormon düzeylerinin ciddi iskemi ile iliþkisi

Fatih Borlu¹, Ali Özgür Öztürk¹, Kerim Küçükler¹, Songül Peker¹, Nihat Özer^2
1Þiþli Etfal Eðitim ve Araþtýrma Hastanesi, 3. Çocuk Kliniði, Ýstanbul
²Siyami Ersek Kalp ve Damar Göðüs Cerrahisi Merkezi, Ýstanbul

Amaç: Klinik ve laboratuvar olarak koroner arter hastalýðý(KAH) olan postmenopozal kadýnlarda serum serbest testosteron ve östradiol düzeyleri ile mevcut koroner iskemi arasýnda iliþki olup olmadýðý araþtýrýldý.
Materyal ve Metod: KAH’lý 94 kadýn ve 46 saðlýklý kadýn alýndý. Gruplar klinik, biyokimyasal, anjiografýk, egzersiz testleri ve SPECT sonuçlarýna göre normal, hafýf-orta ve ciddi iskemi olarak ayrýldý ve bunlarda östradiol ve serbest testosteron hormonlarý bakýldý.
Bulgular: Östradiol düzeyi ciddi iskemik grupta diðer gruplara göre anlamlý þekilde azalmýþ bulundu(p<(),01).Serbest testosteron düzeyi ciddi iskemik grupta diðer gruplara göre anlamlý derecede yüksek iken(p=0,02),total testosteron açýsýndan fark bulunmadý.
Sonuç: Bu çalýþmamýzýn sonuçlarý,ciddi KAH olan postmenopozal kadýnlarda hormon replasman tedavisinin ne derecede gerekli olduðunu vurgulayýcý ve tereddütleri giderici niteliktedir.

Anahtar Kelimeler: Koroner arter hastalýðý, postmenopozal kadýnlar, endojen seks hormonlarý

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