Diagnostic value of serum ferritin, c-reactive protein, Iron and total iron binding capacity in metastatic and non metastatic breast cancer patients
Berna Aslan, Fatma Turgay, Şebnem Ciğerli, Nihal Yücel, Nezaket Eren, Emel YorgancıBiochemistry Laboratory, Şişli Etfal Training and Research Hospital, Istanbul, TurkeyObjective: In this current study, we investigated the iron (FE), total iron binding capacity (TIBC), ferritin, and C-reactive protein (CRP) levels in breast cancer patients with and without metastasis.
Study Design: To this aim, 40 breast cancer women, 20 with metastasis, 20 without metastasis, and a control group of 20 healthy women were included in the study. Ferritin, iron, and TIBC were measured in Hitachi 717 autoanalyser, and CRP levels were detected by nephelometric method.
Results: The mean serum ferritin level was 60.60 ng/ml in control group (group 1), 59.55 ng/ml in non-metastatic patient group (group 2), and there was not any significant difference between this two groups (p>0.90). Contrarily, the mean ferritin level was 427.25 ng/ml in metastatic patient group (group 3), and this was significantly different from the means of group 1 and 2 (p<0.001, p<0.001). Serum iron levels’ means were respectively 65.75 pg/dl, 83.40 pgldL, 66, 0 pg/dl in group 1, 2, and 3. There was not any difference between group 3 versus group land 2 (p>0, 9, p>0,1). The mean serum TIBC level was 302.15 pg/dl in group 1 and 366.20 pg/dl in group 2, and there was a significant difference between two groups (p< 0.001). On the other hand, the mean TIBC level of group 3 was 312.75 pg/dl, and this was significantly different from group 2 (p<0.020) but did not show any difference from group 1 (p: 0.3-0.5). The mean serum CRP level was 0.75 mg/l in group 1, 2.20 mg/l in group 2, and there was not any significant difference between two groups (p>0.3). This value was 42.25 mg/l in group 3, and it was significantly different from group 1 and 2 (p<0.001).
Conclusions: We found that serum CRP, TIBC, and ferritin values were significantly different in metastatic breast cancer patients than those of non-metastatic breast cancer patients and those of healthy control indivuduals.
Nonmetastatik ve metastatik meme kanserli hastalarda serum ferritin, c- reaktif protein, demir ve total demir bağlama kapasitesi düzeylerinin tanısal değeri
Berna Aslan, Fatma Turgay, Şebnem Ciğerli, Nihal Yücel, Nezaket Eren, Emel YorgancıŞişli Etfal Eğitim ve Araştırma Hastanesi, Biyokimya Laboratuvarı, İstanbulAmaç: Çalışmamızda metastazlı ve metastazsız meme kanserli kadınlarda demir (Fe), Total demir bağlama kapasitesi (TDBK), ferritin ve C-reaktif protein (CRP) düzeylerini araştırdık.
Gereç ve Yöntem: Bu amaçla yaşları 30-77 arasında 20 metastazsa, 20 metastazlı, 40 meme kanserli kadın hasta ve 20 kişilik kontrol grubu, çalışmaya alındı. Ferritin, demir, TDBK seviyelerine Hitachi 717 otoanalizöründe, CRP düzeylerine nefelometrede bakıldı.
Bulgular: Serum ferritin düzeyi kontrol grubunda (grup 1) ortalama 60.60 ng/ml, non-metastatik kanserli hastalarda (grup 2) 59.55 ng/mL olarak bulundu ve iki grup arasında anlamlı bir fark bulunamadı (p>0.9). Buna karşılık, metastatik kanserli hastalarda (grup 3) 427.25 ng/ml olup, grup 3 ile grup 1 ve grup 2 arasında anlamlı bir fark bulundu (p<0.001, p<0.001). Serum demir düzeyi ortalama değeri grup 1‘de 65.75 pgldl, grup 2‘de 83.40 pg/dl, grup 3‘de ise 66, 0 pg/dl olup, grup 3 ile grup 1 ve grup 2 arasında anlamlı bir fark bulunamadı (p>0, 9, p>0, 1). Serum TDBK düzeyi ortalama değeri grup l’de 302.15 pg/dl, grup 2’de 366.20 pgldl olup iki grup arasında anlamlı bir fark bulundu (p<0. 001), grup 3’de ise 312.75 pg/dl olup, grup 3 ile grup 1 arasında anlamlı bir fark bulunamazken (p: 0.3-0.5), grup 2 ile arasında anlamlı bir fark bulundu (p<0.02). CRP düzeyi ortalama değeri grup 1 de 0.75 mg/l, grup 2 de 2.20 mgtl olup, iki grup arasında anlamlı bir fark bulunamadı (p>0.3) grup 3‘te ise 42.25 mg/l olup, grup 3 ile grup 1 ve grup 2 arasında anlamlı bir fark bulundu (p<0.001).
Sonuçlar: Metastazlı hasta grubunda serum CRP, TDBK ve ferritin düzeylerinin kontrol ve non-metastatik hastalara göre daha anlamlı şekilde yükseldiğini bulduk.
Manuscript Language: Turkish