Med Bull Sisli Etfal Hosp. 2001; 35(4): 69-71

Rosai-Dorfman disease affecting the subglottic area and submandibular lymph nodes

Emine Yetkin¹, Deniz Özcan², Pýnar Özay², Cem Çomunoðlu², Yalçýn Varnalý³, Halil Akbörü^4
1Department of Pathology, SSK Bandýrma Hospital, Istanbul, Turkey
²Department of Pathology, SSK Istanbul Okmeydaný Training Hospital, Istanbul, Turkey
³Department of Otorhinolaryngology, SSK Istanbul Okmeydaný Training Hospital, Istanbul, Turkey
⁴Department of Oncology, SSK Istanbul Okmeydaný Training Hospital, Istanbul, Turkey

Objective: Rosai-Dorfmann Disease ( Sinus histiocytosis with massive Iymphadenopaty-SHML) is a rare, idiopathic, histiocytic proliferative disorder that most commonly involves the cervical lymph nodes. The typical clinical features of this disease include bilateral painless lymph node enlargement, fever, leucocytosis, elevated eiythrocyte sedimentation rate, policlonal hypergammaglobulinemia. Generally, this is a benign reactive disorder, have an indolent clinical course; but have a highly variable biological behaviour. Here we report a case of Rosai Dorfmann Disease affecting the subglottic area and submandibular lymph nodes and discussed in the view of the literature.

Keywords: Subglottic area, submandibular lymph nodes, sinus histiocytosis, massive lymphadenopathy.

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Subglottik Bölge Submandibuler Lenf Bezleri Yerleþimli Rosai-Dorfman Hastalýðý

Emine Yetkin¹, Deniz Özcan², Pýnar Özay², Cem Çomunoðlu², Yalçýn Varnalý³, Halil Akbörü^4
1SSK Bandýrma Hastanesi, Patoloji Kliniði, Ýstanbul
²SSK Ýstanbul Okmeydadý Eðitim Hastanesi, Patoloji Kliniði, Ýstanbul
³SSK Ýstanbul Okmeydadý Eðitim Hastanesi, Kulak Burnu Boðaz Kliniði, Ýstanbul
⁴SSK Ýstanbul Okmeydadý Eðitim Hastanesi, Onkoloji Kliniði, Ýstanbul

Amaç: Rosai - Dorfman Hastalýðý (Yaygýtý Letýfadenopatili Sinüs Histiyositozu) lenf nodlantýýn histiyosit proliferosyonuyla giden, özellikle servikal lenf nodlamýý tutan, idiopotik, nadir rastlanan bir hastalýðýdýr. Tipik klinik özellikleri bilateral aðrýsýz lenf nodýý büyümesi, ateþ, lökositoz, sedimantasyon artýþý, poliklonal hipergammaglobýýlinemidir. Genellikle benign reaktif bir dunundur, yavaþ klinik gidiþ gösterir, fakat oldukça deðiþken bir biyolojik davranýþa sahiptir. Çalýþmamýzda subglottik bölge ve submandibuler lenf bezleri yerleþimli bir Rosai Dorfman Hastalýðý (RDH) olgusu sunuldu ve literatür bilgileri ýþýðýnda tanýþýldý.

Anahtar Kelimeler: Subglottik bölge, submandibular lenfmodlan, sinus histiyositosis, massif lenfadenopati.

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