Med Bull Sisli Etfal Hosp. 2020; 54(4): 405-410 | DOI: 10.14744/SEMB.2020.01709

The Relationship between Vitamin D Level and Lower Urinary Tract Symptoms in Women

Sibel Serin¹, Ozlem Pehlivan¹, Aysun Isiklar², Ahmet Tahra³, Sema Basat^1
1Department of Internal Medicine, University of Health Sciences Turkey, Umraniye Training and Research Hospital, Istanbul, Turkey
²Department of Internal Medicine, Acibadem Hospitals Group, Istanbul, Turkey
³Department of Urology, University of Health Sciences Turkey, Umraniye Training and Research Hospital, Istanbul, Turkey

Objectives: In the literature, the effects of vitamin D on lower urinary tract symptoms (LUTS) have been investigated. Conflicting results have been reported in these studies conducted. LUTS is more common in women. In this study, we aimed to evaluate the relationship between vitamin D and LUTS in female patients using the uroflowmetric method.
Methods: This retrospective cohort study included 186 female patients who were admitted with LUTS. Demographic characteristics, medical history, calcium (Ca) and vitamin D, including laboratory studies and uroflowmetry results, as maximum urine flow rate (Qmax), average urine flow rate (Qav) and voided volume (V) were recorded. Patients were divided into two groups according to age (18-50 and ≥51) and vitamin D levels (<20 and ≥20). Laboratory parameters and uroflowmetry results were compared between groups.
Results: Mean age was 56.85±12.95 years. Mean vitamin D level was 21.19±13.93 ng/mL (2.5-83.5). Mean Qmax value was 35.41±12.63, whereas the mean Qav was 19.13±9.89, and the mean V was 446.60±165.08 mL. Vitamin D levels differed according to age groups (p=0.044). No significant difference was observed between groups according to Qmax, Qav and V values (p>0.05). No significant correlation was detected between vitamin D level and Qmax, Qav and V values. However, a negative correlation was detected between serum Ca level and V values (p=0.042) in the low vitamin D group.
Conclusion: There was no direct relationship between vitamin D levels and LUTS in respect to uroflowmetry. However, we determined that Ca levels affect the uroflowmetry parameter in patients with low vitamin D levels. There is a need for further studies emphasizing serum Ca levels in addition to vitamin D levels in patients with LUTS.

Keywords: Calcium levels, uroflowmetry, lower urinary tract symptoms; vitamin D; women.

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Kadýnlarda D Vitamini Seviyesi ve Alt Üriner Sistem Semptomlarý Arasýndaki Ýliþki

Sibel Serin¹, Ozlem Pehlivan¹, Aysun Isiklar², Ahmet Tahra³, Sema Basat^1
1Saðlýk Bilimleri Üniversitesi, Ümraniye Eðitim ve Araþtýrma Hastanesi, Ýç Hastalýklarý Kliniði, Ýstanbul
²Acýbadem Hastaneler Grubu, Ýç Hastalýklarý Kliniði, Ýstanbul
³Saðlýk Bilimleri Üniversitesi Üroloji Kliniði, Ümraniye Eðitim ve Araþtýrma Hastanesi, Ýstanbul

Amaç: Literatürde D vitamininin alt üriner sistem semptomlarý (LUTS) üzerindeki etkisi ile ilgili çalýþmalar mevcuttur. Bu çalýþmalarda çeliþkili sonuçlar bildirilmiþtir. LUTS kadýnlarda daha yaygýndýr. Bu çalýþmada kadýn hastalarda D vitamini ve LUTS arasýndaki iliþkiyi, üroflovmetrik yöntemle deðerlendirmeyi amaçladýk.
Material/metod: Bu retrospektif kohort çalýþmaya LUTS ile baþvuran 186 kadýn hasta dahil edildi. Demografik özellikler, týbbi öykü, kalsiyum (Ca) ve D vitamini içeren laboratuvar verileri ve maksimum idrar akýþ hýzý (Qmax), ortalama idrar akýþ hýzý (Qav) ve geçersiz hacim (V) olarak üroflovmetri sonuçlarý kaydedildi. Hastalar yaþ (18-50 ve ≥51) ve D vitamini seviyelerine (<20 ve ≥20) göre iki gruba ayrýldý. Laboratuvar parametreleri, üroflovmetri sonuçlarý gruplar arasýnda karþýlaþtýrýldý.
Bulgular: Yaþ ortalamasý 56,85 ± 12,95 idi. Ortalama D vitamini seviyesi 21.19 ± 13.93 ng / mL (2.5-83.5) idi. Ortalama Qmax deðeri 35.41 ± 12.63 iken ortalama Qav 19.13 ± 9.89 ve ortalama V 446.60 ± 165.08 mL idi. D vitamini düzeyleri yaþ gruplarýna göre farklýlýk gösterdi (p = 0.044). Qmax, Qav ve V deðerlerine göre gruplar arasýnda anlamlý fark gözlenmedi (p> 0.05). D vitamini düzeyi ile Qmax, Qav ve V deðerleri arasýnda anlamlý bir iliþki saptanmadý. Bununla birlikte, düþük D vitamini grubunda serum Ca düzeyi ile V deðerleri (p = 0.042) arasýnda negatif korelasyon saptandý.
Sonuç: Üroflovmetrik açýdan D vitamini düzeyleri ile LUTS arasýnda direkt iliþki bulamadýk. Bununla birlikte, D vitamini düþük olan hastalarda Ca düzeylerinin üroflovmetri parametresini etkilediðini tespit ettik. LUTS hastalarda vitamin D düzeylerine ek olarak serum Ca düzeylerini vurgulayan çalýþmalara ihtiyaç olduðuna inanýyoruz. (SETB-2020-07-114)

Anahtar Kelimeler: Kadýnlar, alt üriner sistem semptomlarý, üroflovmetri, D vitamini, Kalsiyum düzeyleri,

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