Med Bull Sisli Etfal Hosp. 2024; 58(3): 389-394 | DOI: 10.14744/SEMB.2024.65983

Evaluation of Oral Glucose Tolerance Test Results in Children with Cystic Fibrosis

Asli Bestas¹, Edip Unal¹, Amine Aktar Karakaya¹, Nurcan Beyazit¹, Suat Savas², Velat Sen^3
1Department of Pediatric Endocrinology, Dicle University Faculty of Medicine, Diyarbakir, Türkiye
²Department of Pediatrics, Dicle University Faculty of Medicine, Diyarbakir, Türkiye
³Department of Pediatric Pulmonology, Dicle University Faculty of Medicine, Diyarbakir, Türkiye

Aim: Current guidelines suggest that patients with CF, who are over the age of 10, should be annually evaluated with OGTT. In this study, it was aimed to evaluate the OGTT results in patients above the age of 10, who were followed up in our center with the diagnosis of Cystic fibrosis (CF).
Materials and Methods: In the study, 46 patients with CF at the age of 10 and above, who underwent OGTT were included. Data such as gender, age at diagnosis, anthropometric measurements, lung function(FEV1 %) and the OGTT results were obtained. In the analysis, the patient groups with normal glucose tolerance(NGT) and abnormal glucose tolerance(AGT) were compared.
Results: NGT was found in 37(80.4%) of the patients, and AGT was found in 9(19.5%) of the patients. The median fasting glucose levels of the patients in the NGT group and the mean glucose levels measured at 120 minutes in the OGTT were found to be lower compared to the patients in the AGT group(p<0.005). Although the mean body weight, height, VKÝ-SDS, FEV1in the AGT group were found to be lower than the patients in the NGT group, the difference was not statistically significant (p>0.05).
Conclusion: We detected AGT in approximately in 1 out of 5 patients with CF who were at the age of 10 and above. Almost half (44.4%) of the patients with AGT were found to have normal fasting blood glucose levels. Therefore, Cystic fibrosis-related diabetes screening should be performed with OGTT instead of fasting blood glucose in patients with CF.

Keywords: Cystic fibrosis, cystic fibrosis-related diabetes, oral glucose tolerance test

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Kistik Fibrozisli Çocuklarýn Oral Glukoz Tolerans Test Sonuçlarýnýn Deðerlendirilmesi

Asli Bestas¹, Edip Unal¹, Amine Aktar Karakaya¹, Nurcan Beyazit¹, Suat Savas², Velat Sen^3
1Dicle Üniversitesi Týp Fakültesi, Çocuk Endokrinolojisi Anabilim Dalý, Diyarbakýr
²Dicle Üniversitesi Týp Fakültesi, Çocuk Saðlýðý ve Hastalýklarý Anabilim Dalý, Diyarbakýr
³Dicle Üniversitesi Týp Fakültesi, Çocuk Göðüs Hastalýklarý Anabilim Dalý, Diyarbakýr

Amaç: Güncel kýlavuzlar, 10 yaþýn üzerindeki KF’li hastalarýn yýllýk olarak OGTT ile deðerlendirilmesi gerektiðini önermektedir. Bu çalýþmada merkezimizde kistik fibrozis (KF) tanýsýyla takip edilen 10 yaþ üstü hastalarda OGTT sonuçlarýnýn deðerlendirilmesi amaçlandý.
Gereç ve yöntemler: Çalýþmaya OGTT uygulanan 10 yaþ ve üzeri 46 KF hastasý dahil edildi. Cinsiyet, taný yaþý, antropometrik ölçümler, akciðer fonksiyonu (%FEV1) ve OGTT sonuçlarý gibi veriler elde edildi. Analizde normal glukoz toleransý(NGT) ve anormal glukoz toleransý(AGT) olan hasta gruplarý karþýlaþtýrýldý.
Bulgular: Olgularýn 37’sinde (%80,4) NGT, 9’unda (%19,5) AGT saptandý. Normal glukoz tolerans grubundaki olgularýn median açlýk glukoz ve OGTT sýrasýnda alýnan 120.dakikadaki ortalama glukoz düzeyleri AGT grubuna göre daha düþük saptandý (p<0,005). Anormal glukoz tolerans grubundaki olgularýn, ortalama vücut aðýrlýðý, boy, VKÝ SDS deðerleri, FEV1 yüzdesi NGT’li olgu grubuna göre daha düþük saptanmakla beraber aradaki fark istatistiksel olarak anlamlý bulunmadý (p>0,05).
Sonuç: 10 yaþ ve üzeri KF’li yaklaþýk 5 hastadan 1'inde AGT tespit ettik. AGT’li hastalarýn neredeyse yarýsýnýn (%44,4) açlýk kan þekerinin normal olduðu görüldü. Bu nedenle KF’li hastalarda açlýk kan þekeri yerine OGTT ile kistik fibrozis iliþkili diyabet taramasý yapýlmalýdýr. (SETB-2024-02-030)

Anahtar Kelimeler: Kistik fibrozis, kistik fibrozise baðlý geliþen diyabet, oral glukoz tolerans testi

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