Effect of Chemo-radiotherapy on Survival in Locally Advanced Nasopharynx Cancers

PURPOSE: We evaluated the effect of neoadjuvant chemotherapy and radiotherapy on survival in locally advanced nasopharynx cancers.
MATERIAL AND METHOD: The study included 42 patients who applied to the Radiation Oncology Clinics of Şişli Etfal Hospital between 1991 and 1997. All the patients received neoadjuvant chemotherapy and radiotherapy. Survival rates of 40 patients were retrospectively assessed.
RESULTS: Thirty patients were males (70.1%) and 12 were females (29.9%). Average age was 51 years (range, 12- 66 years). Twenty-nine patients (69%) had indifferentiated carcinoma and 13 patients (31%) had squamous cell carcinoma.
CONCLUSION: Follow-up period ranged from 6 months to 66 months, with mean and median follow-up periods being 29 and 40 months, respectively. Two and three year survival rates were higher in patients with indifferentiared carcinoma.

Lokal İleri Evre Nazofarenks Kanserlerinde Neoadjuvan Kemo-Radyoterapinin Sağkalým Üzerine Etkisi

AMAÇ: Bu çalýşmada neoadjuvan kemoterapi ve radyoterapinin lokal ileri evre nazofarenks kanserlerinde sağ kalým üzerindeki etkisi incelenmiştir.
MATERYAL VE METOD: Şişli Etfal Hastanesi Radyasyon Onkolojisi Kliniği'ne, 1991-1997 yýllarý arasýnda müracaat eden 42 hasta çalýşma kapsamýna alýndý. Hastalarýn tümüne neoadjuvan kemoterapi ve radyoterapi uygulandý. 42 hastanýn 40'ýnda sağ kalým oranlarý retrospektif olarak analiz edildi.
BULGULAR: Hastalarýmýzýn 10'u erkek (%70.1), 12'si kadýndýr (%29.9). Mediyan yaş 51'dir (12-66 yaş). 29 hastada indiferansiye karsinom (%69), 13 hastada skuamöz hücreli karsinom (%31) tespit edilmiştir.
SONUÇ: Çalýşma grubumuzda minimum izlem süresi 6 ay, maksimum izlem süresi 66 aydýr, aritmetik ortalama 29 ay ve medyan ortalama 40 aydýr. İndiferansiye karsinomalý hastalarda 2 ve 3 yýllýk sağ kalým oranlarý daha yüksek bulunmuştur.