Med Bull Sisli Etfal Hosp. 2010; 44(3): 131-133

Fetal intracranial hemorrhage associated with alloimmune thrombocytopenia

Emrah Can, Muhittin Çelik, Ali Bülbül, Sinan Uslu, Selda Arslan
Þiþli Etfal Eðitim ve Araþtýrma Hastanesi Neonatoloji Kliniði, Ýstanbul - Türkiye

Cerebral hemorrhage during fetal period may be related to various etiologies. The frequency of intraventricular hemorrhage in neonates is reported to be 25-45%. Neonatal alloimmune thrombocytopenia (NAIT) develops when fetal thrombocytes lack an antigen which is derived either from mother or the father. Typically affected newborns are healthy after birth and during early postnatal period, they may show moderate or severe symptoms including fetal intracranial hemorrhage related to the degree of thrombocytopenia. A newborn with an antenatal diagnosis of fetal intracranial hemorrhage who postnatally was found to have NAIT was presented in this case report.

Keywords: Fetal intracranial haemorrage, alloimmune thrombocytopenia, cranial ultrasonography

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Alloimmun trombositopeni iliþkili fetal intrakraniyal kanama

Emrah Can, Muhittin Çelik, Ali Bülbül, Sinan Uslu, Selda Arslan
Þiþli Etfal Eðitim ve Araþtýrma Hastanesi Neonatoloji Kliniði, Ýstanbul - Türkiye

Fetal dönemde serebral kanama oldukça farklý nedenlere baðlý olarak geliþen patolojik bir durumdur. Yenidoðanda ventriküller içi kanama sýklýðý yaklaþýk %25-45 oranýnda bildirilmektedir. Neonatal alloimmun trombositopeni fetal trombositlerin baba veya anne kaynaklý olarak bir antijenden yoksun kalmasý durumunda gerçekleþmektedir. Yenidoðanlar tipik olarak saðlýklý iken, erken postnatal dönemde trombositopenin derecesi ile orantýlý olarak fetal intrakranial kanama dahil olmak üzere orta ve þiddetli bulgular gösterebilir. Bu yazýda antenatal dönemde tespit edilen fetal intrakraniyal kanama olgusunda postnatal taný konulan alloimmun trombositopeni sunulmuþtur.

Anahtar Kelimeler: Fetal intrakranial kanama, alloimmun trombositopeni, kranial ultrasonografi

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