Local radiotherapy in low grade astrocytomas summary

Objective: To evaluake the result of treatement methods of the patient who were treated at our clinic between 01.01.1988 and 08.09.1996 with Low Grade Asrocytomas diagnosis.
Study Design: Patient group were studied in post and preoperation findings with regard to application of radiotherapy. This was left out as our purpose was to evulate the resluts of radiotherapy. Ki-sq test and Mann-Whitney U test were used for statistical calculations.
Results: 78.4% of patients were complaing from headaches when they come to our clinic, 58.4% had epileptical synptoms. 56.7% of the patient were grouped as falling into stage I, All the patient had a operational treatments and all had been diagnosed as hystopathological. 9 patients received primer radiotherapy,56 patients had postoperative radiotherapy, grade 1 pat ie nets, were followed for up to 40 months, grade II for 25.6 months,. Average follow-up of the patients between grade I and grade II show a remarkable difference (p>0.05)
Conclusion: Low Grade Astrocytomas Form the 15-20% of intracrainal neoplasms, primer treatments is considered as “ Operative’’ and our patients had been obsereved to be 15- 35% operative rezeciton. Before, the treatment was made using parallel-oposite ray applications over the whole of the brain but recently, the developments in tomography and MR allows us to use localy concetrated Rays.

Low Grade Astrositomlu Vakalarda Lokal Radyoterapi

Amaç: 01.01.1988 / 08.09.1996 tarihleri arasýnda kliniðimize baþvuran low grade astrositoma tanýsý almýþ hastalarýn tedavi sonuçlarýnýn deðerlendirilmesini amaçladýk.
Materyal Metod: Hasta grubunun özelliði primer veya postoperatif radyoterapi uygulanmýþ olmasýdýr. Niiks veya rezidiv sebebiyle kemoterapi uygulanan hastalar; primer amacýmýzýn radyoterapi etkinliðini incelemek olduðu için çalýþma dýþý býrakýlmýþtýr, lstatistiki olarak Ki-kare testi ve Mann-Whitney U testi kullanýlmýþtýr.
Bulgular: Hastalarýn ilk baþvuru semptomlarý içinde baþ aðrýsý ( %.78.4) birinci sýrada, epileptik nöbet (%58.4) ikinci sýradadýr. Hastalarýn %56.7’sinin stage 1 hastalar oluþturmaktadýr. Çalýþmamýza alýnan hastalarýn tümüne cerrahi bir prosedür uygulanmýþ ve histopatolojik olarak taný konulmuþtur Hastalarýn 9’una primer radyoterapi, 56’sýna ise postoperatif radyoterapi uygulanmýþtýr. Grade 1 hastalarda ortalama takip süresi 40 ay, grade II hastalarda 25.6 aydýr. Ortalama takip süresi açýsýndan grade 1 ve grade II hastalar arasýnda istatistiki olarak anlamlý bir farklýlýk vardýr. (U: 311, p>0.05)
Sonuç: Low grade astrositomalar intrakraýýyal neoplazmalarýn yaklaþýk %15-20’siniýý teþkil ederler Primer tedavisi cerrahi olup, hastalann % 15-35’i cerrahi rezeksiyona uygundur Daha önceleri paralel karþýlýklý lateral iki sahadan yapýlan tüm beyin ýþýnlamasý, bugün beyin tomografisi ve magnetik rezonans tekniklerindeki geliþmelerle birlikte yerini lokal ýþýnlamaya býrakmýþtýr.