Med Bull Sisli Etfal Hosp. 2016; 50(2): 137-141 | DOI: 10.5350/SEMB.20160216020543

Evaluation of neutrophil-lymphocyte ratio and mean platelet volume in patients with psoriasis

Aslý Aksu Çerman, Ezgi Aktaþ Karabay, Ýlknur Kývanç Altunay
Þiþli Hamidiye Etfal Eðitim ve Araþtýrma Hastanesi, Dermatoloji Kliniði, Ýstanbul - Türkiye

Objective: Psoriasis is a chronic, inflammatory, systemic disease. Psoriasis Area and Severity Index (PASI) is used to evaluate the disease activity and response to therapy in psoriasis patients. However, more objective laboratory tools should be developed beside PASI. Neutrophil-lymphocyte ratio and mean platelet volume are inflammatory biomarkers that are known to be evaluated in various inflammatory diseases. The purpose of this study was to analyse the levels of neutrophil-lymphocyte ratio and mean platelet volume in psoriasis patients and to investigate the relationship between these biomarkers and the disease activity.
Materials and Methods: Fourty-nine patients with chronic plaque psoriasis and 47 controls were included in the study. Neutrophil-lymphocyte ratio and mean platelet volume values of two groups were retrospectively evaluated.
Results: Neutrophil-lymphocyte ratio levels were significantly higher in patients with psoriasis than in healthy controls (p<0.001). The levels of mean platelet volume did not show statistically significant difference between psoriasis patients and controls (p=0.061). When psoriasis patients were evaluated according to disease severity, no correlation was found between the disease activity and neutrophillymphocyte
ratio and mean platelet volume values (p>0.05).
Conclusion: In the recent studies, it has been mentioned that the neutrophil-lymphocyte ratio and mean platelet volume have prognostic importance for cardiovascular diseases. Assessment and management of the inflammatory status in psoriasis patients is important to prevent the comorbidities such as cardiovascular diseases. With this purpose, neutrophil-lymphocyte ratio might be considered as an easily accessed, available and cost-effective laboratory marker.

Keywords: Neutrophil lymphocyte ratio, mean platelet volume, psoriasis vulgaris.

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Psoriazisli hastalarda nötrofil lenfosit oraný ve ortalama trombosit hacminin deðerlendirilmesi

Aslý Aksu Çerman, Ezgi Aktaþ Karabay, Ýlknur Kývanç Altunay
Þiþli Hamidiye Etfal Eðitim ve Araþtýrma Hastanesi, Dermatoloji Kliniði, Ýstanbul - Türkiye

Amaç: Psoriazis, kronik, inflamatuar, sistemik bir hastalýktýr. Psoriaziste hastalýk þiddetini ve tedaviye yanýtý deðerlendirmede Psoriazis Alan ve Þiddet Ýndeksinin (PAÞÝ) yanýsýra daha objektif laboratuvar araçlarýna ihtiyaç vardýr. Nötrofil lenfosit oraný ve ortalama trombosit hacmi çeþitli inflamatuar hastalýklarda arttýðý bilinen inflamatuar belirteçlerdir. Bu çalýþmada amacýmýz psoriazisli hastalarda nötrofil lenfosit oraný ve ortalama trombosit hacmi deðerlerini incelemek ve hastalýk þiddetiyle iliþkisini deðerlendirmektir.
Gereç ve Yöntemler: Kýrk dokuz kronik plak tip psoriazisli hasta ve 47 kontrolün nötrofil lenfosit oraný ve ortalama trombosit hacmi retrospektif olarak deðerlendirildi.
Bulgular: Psoriazisli hastalarda nötrofil lenfosit oraný kontrollerden anlamlý olarak yüksek bulundu (p<0.001). Ortalama trombosit hacmi yönünden her iki grup arasýnda anlamlý bir fark saptanmadý (p=0.061). Psoriazisli hastalar hastalýk þiddetine göre incelendiðinde nötrofil lenfosit oraný ve ortalama trombosit hacmi yönünden herhangi bir korelasyon saptanmadý (p>0.05).
Sonuç: Son yýllardaki çalýþmalarda, kardiyovasküler hastalýklarda nötrofil lenfosit oraný ve ortalama trombosit hacminin prognostik önemi olduðu üzerinde durulmaktadýr. Psoriazisli hastalarda sistemik inflamasyonun belirlenmesi ve tedavisi kardiyovasküler hastalýklar gibi eþlik edebilecek komorbiditelerin de azaltýlabilmesi bakýmýndan önemlidir. Bu amaçla nötrofil lenfosit oraný kullanýþlý, kolay ulaþýlabilir ve ucuz bir laboratuvar parametre olabilir

Anahtar Kelimeler: Nötrofil lenfosit oraný, ortalama trombosit hacmi, psoriazis vulgaris.

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