Comparison of the Effects of Metoclopramide and Ondansetron on Emergency Service Observation Times in Acute Gastroenteritis-Related Nausea and Vomiting Cases

Objectives: The aim of the present study was to compare the effect of metoclopramide and ondansetron treatments on the emergency department observation time in acute gastroenteritis-related nausea and vomiting (NV).
Methods: The study was conducted retrospectively on 297 patients diagnosed with acute gastroenteritis in a training and research hospital's emergency service observation unit within 6 months. Patients with gastroenteritis who were diagnosed with NV were divided into two groups according to the treatment they received in the observation unit. Patients who received 4 mg ondansetron slow infusion therapy were classified as Group 1, and patients who received 10 mg metoclopramide slow infusion therapy were classified as Group 2.
Results: The average age of the patients was 39.57±18.75 years. Of the 297 participants, 56.6% (168) were female. Among them, 51.5% (153) received ondansetron (Group 1), and 48.5% (144) received metoclopramide (Group 2). 6.9% weakness–numbness and 4.9% akathisia were detected due to metoclopramide use. There were no adverse effects related to ondansetron use. The duration of observation ranged from 19 to 75 min in Group 1 and from 42 to 122 min in Group 2. Nineteen (13.2%) patients in Group 2 and 5 (3.3%) patients in Group 1 revisited the emergency department within 24 h due to ongoing complaints.
Conclusion: In conclusion, side effects of weakness and akathisia due to metoclopramide use were observed. However, no side effects were observed due to ondansetron use. Additionally, the use of ondansetron showed a shorter observation time and less recurrent admission to the emergency department. Therefore, ondansetron is a more effective drug in the treatment of NV associated with acute gastroenteritis.

Akut Gastroenterit Ýliþkili Bulantý ve Kusma Olgularýnda Metoklopramid ve Ondansetronun Acil Servis Gözlem Sürelerine Etkilerinin Karþýlaþtýrýlmasý

Amaç: Bu çalýþmada akut gastroenterite baðlý bulantý ve kusmada metoklopramid ve ondansetron tedavilerinin acil servis gözlem sürelerine etkisini karþýlaþtýrmak amaçlandý.

Gereç ve Yöntem: Bu çalýþma, 6 aylýk süre içerisinde, bir eðitim ve araþtýrma hastanesinin acil servis gözlem ünitesinde, akut gastroenterit tanýsý alan 297 hasta üzerinde geriye dönük olarak gerçekleþtirildi. Bulantý ve kusma þikayetleri ile gelen gastroenterit tanýlý hastalar gözlem ünitesinde aldýklarý tedaviye göre iki gruba ayrýldý. Ondansetron 4 miligram (mg) infüzyon tedavisi alan hastalar Grup 1 olarak ve metoklopramid 10 mg infüzyon tedavisi alan hastalar Grup 2 olarak kabul edildi.

Bulgular: Yaþ ortalamasý 39,57 ± 18,75 idi; Katýlýmcýlarýn yüzde 56,6'sý (168) kadýndý. Hastalarýn 51.5%'i (153) ondansetron (Grup 1) ve 48.5%'i (144) metoklopramid (Grup 2) tedavisi almýþtý. Grup 1'de gözlem süresi 19 ile 75 dakika arasýnda, Grup 2'de 42 ile 122 dakika arasýnda deðiþmiþtir. Grup 2'deki 19 hasta (13,2%) ve Grup 1'deki 5 hastanýn (3,3%) devam eden þikayetler nedeniyle 24 saat içinde acil servise tekrar baþvurduðu görüldü.

Sonuç: Çalýþmada metoklopramid kullanýmýna baðlý 6.9% güçsüzlük-uyuþukluk, 4.9% akatizi tespit edildi. Ondansetron kullanýmýna baðlý yan etki görülmedi. Bununla birlikte ondansetron kullanýmýnda daha kýsa gözlem süresi ve acil servise daha az tekrarlayan baþvuru saptandý. Bulgularýmýz akut gastroenterit ile iliþkili bulantý ve kusma tedavisinde ondansetronun daha etkili bir ilaç olduðunu göstermektedir.