Autologous serum skin test of patients with chronic urticaria

Objective: Chronic urticaria (CU) is a common skin disorder Previous studies defining the clinical features of patients with chronic idiopathic urticaria (CIU) were performed before the identification of functional autoantibodies against Fc_Rl.Some recent studies showed that approximately one- third of patients with CIU had circulating functional autoantibodies against the high affinity IgE receptor FcJRI and/or IgE. We aimed to use Autologous Serum Skin Test (ASST) in the patients with CU.
Study design: Between October 2000-April 2001, ASST were performed in 30 CU patients and 10 healty controls. We used 0. 1 ml autologous serum and 0.9% phosphate buffered saline solution on both forearms.
Results: ASST were positive 24 (80%) out of 30 patients with CU and ASST were positive,4 out of 10 healty controls. The difference was significant as statisticall.
Conclusion: Chronic urticaria remains a major problem in terms of etiology, investigation and management. As a result of this study we can use ASST in patients who had chronic urticaria as pretest.

Kronik ürtikerli olgularda otolog serum deri testi

Amaç: Kronik ürtiker (KÜ) yaygýn bir hastalýktýr. Daha önce yapýlan klinik çalýþmalarda kronik idyopatik ürtikerli hastalarda Fc_RI fonksiyonel otoantikorlarý tespit edilmiþtir.Yakýn zamandaki bazý çalýþmalarda da KÝÜ’ li hastalarýn 1/3’de IgE’ ye ve/veya IgE Fc_Rl reseptörlerine karþý yüksek afinite gösteren fonksiyonel otoantikorlar gösterilmiþtir. Bizim amacýmýz da, Otolog Serum Deri Testini (OSDT) kronik ürtikerli hastalarda uygulamaktý.
Gereç ve Yöntem: Ekim 2000-Nisan 2001 arasýnda; 30 KÜ’ li ve 10 saðlýklý kontrol grubu alýndý. 0.1 mi‘ li otolog serum ve %0.9fosfatla tamponlarmýþ serum fizyolojik her iki ön kola uygulandý.
Bulgular: Kronik ürtikerli 30 hastanýn 24’ ünde (%80) OSDT pozitif bulundu ve 10 saðlýklý kontrol grubunun da 4’ ünde OSDT pozitif bulundu. Fark istatistiksel olarak anlamlýydý. Sonuç: : Kronik ürtikerde en büyük problem etyoloji, teþhis ve tedavidir.Bundaýý dolayý OSDT’ niýý kronik ürtikerli hastalarda bir pretest olarak kullanýlabilirliðinin sonucuna vardýk.