Med Bull Sisli Etfal Hosp. 2007; 41(2): 31-35

The effect of topical latanoprost on retrobulbar blood flow in patients with primary open angle glaucoma and ocular hypertension

Ersin Oba, Ulviye Yiðit, Fatma Koca, Burcu Dirim, Alper Özel, Muzaffer Baþak
Þiþli Etfal Training and Research Hospital, Istanbul, Turkey

Purpose: To investigate the effects of topical latanoprost 0,005% on retrobulbar vessel blood velocity in patients with primary open-angle glaucoma (POAG), norrnotansive glaucoma (NTG) or ocular hypertension (OH).
Material and Method: Twenty patients with POAG, NTG or OH were enrolled for this study All patients were treated topically with latanoprost 0. 005 % (Xalatan). Follow-up time was three months. Each patient had a baseline color Doppler Imaging ultrasound of the central retinal artery, posterior ciliary artery, ophtalmic artery and second color doppler ultrasound examination three months later. Intraocular pressure (IOP) in each patient was also recorded with Goldman applanation tonometer before the treatment and at the end of three months follow-up.
Results: Twenty patients completed the study. Topical latanoprost significiantly reduced intraocular pressure (p<0.05) The only significant change observed in the retrobulbar blood velocity with latanoprost treatment was an increase of end diastolic velocity in the posterior ciliary artery (p<0.05). No change in the other blood velocity measurements was observed with latanoprost treatment.
Conclusion: Topical latanoprost significantly reduced the intraocular pressure in ocular hypertensive and glaucoma patients and didn’t make unexpected changes on retrobulbar blood flow; also made an increase of end diastolic velocity in the posterior ciliary artery.

Keywords: Latanoprost, Retrobulbar blood flow, primary open angle glaucoma, Ocular hypertension, Norrnotansive glaucoma, Color Doppler imaging

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Açýk açýlý glokom ve oküler hipertansiyon olgularýnda topikal latanoprostun retrobulber kan akýmý üzerine etkisi

Ersin Oba, Ulviye Yiðit, Fatma Koca, Burcu Dirim, Alper Özel, Muzaffer Baþak
Þiþli Etfal Eðitim ve Araþtýrma Hastanesi, Ýstanbul

Amaç: Primer açýk açýlý glokom (PAAG),normotansif glokom (NTG) veya oküler hipertansiyon (OH) tanýsý alan hastalarda %0. 005 topikal latanoprost‘un retrobulber kan akýmý üzerindeki etkisini araþtýrmak.
Gereç ve yöntem: PAAG, NTG veya OH tanýsý konan 20 hastanýn 34 gözünde tedavi amacýyla Latanoprost % 0,005 (Xalatan) baþlandý. Tüm hastalarda tedaviye baþlamadan önce ve tedavi sonrasý üçüncü ayda oftalmik arter (OA), santral retinal arter (SRA), posterior siliyer artere (PSA) ait renkli Doppler ultrasonografi yapýldý. Tedavi öncesi ve sonrasý üçüncü ayda Goldman applanasyoýý tonometresi ile göz içi basýnç (GÝB) ölçümleri kaydedildi.
Bulgular: Hastalarýn hepsinde üçüncü ayýn sonunda GÝB anlamlý olarak daha düþük bulundu (p<0 05). Latanoprost tedavisiyle retrobulber damarlardaki kan akým hýzlarýnda anlamlý tek deðiþiklik posterior silyer arter end diastolik hýzýndaki artýþ olarak gözlendi (p<0 05). Latanoprost tedavisi sonrasý 3. ayda ölçülen diðer kan akýný hýzý ölçümlerinde anlamlý bir farklýlýk bulunmadý.
Sonuç: Latanoprostun 3 aylýk dönem sonunda GÝB’i anlamlý olarak düþürdüðü, istenmeyen retrobulber hemodinamik deðiþiklikler oluþturmadýðý ve posterior silyer arterin end diastolik hýzýnda artýþ saðladýðý saptanmýþtýr.

Anahtar Kelimeler: Latanoprost, Retrobulber kan akýmý Primer açýk açýlý glokom, Oküler hipertansiyon, Normotansif glokom, Renkli Doppler Ultrasonografi

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