Med Bull Sisli Etfal Hosp. 2022; 56(2): 196-201 | DOI: 10.14744/SEMB.2021.07348

Evaluation of Peripapillary and Macular Vascular Flow Changes with OCT-A in Patients with Superficial Optic Disk Drusen

Ibrahim Cagri Turker, Saniye Uke Uzun, Ceylan Uslu Dogan, Burcu Dirim, Emine Betul Akbas Ozyurek, Sumeyra Keles Yesiltas, Dilek Guven
Department of Ophthalmology, University of Health Sciences Turkey, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey

Objectives: The purpose of this study was to compare the peripapillary and macular vascular flow changes between healthy adults and adult patients with superficial optic disk drusen (ODD), as evaluated by optical coherence tomography angiography (OCT-A).
Methods: In this retrospective study, 44 eyes of 22 patients with superficial ODD followed-up in our neuro-ophthalmology unit and 54 eyes of 27 healthy individuals admitted to our clinic for routine ophthalmological examination were included in the study. The superior, inferior, nasal, and temporal radial peripapillary capillary plexus (RPC) vessel density (VD) values; superior, inferior, nasal, and temporal parafoveal and foveal region superficial capillary plexus (SCP) and deep capillary plexus (DCP) VD values; and choriocapillaris flow (CCF) area and foveal avascular zone area were evaluated by OCT-A.
Results: There was no statistically significant difference between groups in terms of age and sex. While there was a significant decrease in the temporal RPC VD values in cases with ODD (p=0.02), no significant difference was observed in other quadrants. No significant differences in either parafoveal zone four quadrant, foveal SCP and DCP VD values, or foveal avascular zone measurements were found between groups, while CCF area values were significantly higher in the study group (p=0.012).
Conclusion: Compared to healthy controls, our results showed a decrease in the RPC temporal quadrant VD values, and an increase in CCF area in cases with superficial ODD. To evaluate the effects of ODD on optic nerve head and macular perfusion, and to understand its underlying mechanisms and secondary complications, longer follow-up studies with larger case series are needed.

Keywords: Macular vascular flow, neuro-ophthalmology, optic disk drusen, optical coherence tomography angiography, peripapillary vascular flow, retina

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Yüzeyel Optik Disk Drusenli Hastalarda OCT-A ile Peripapiller ve Maküler Vasküler Akým Deðiþikliklerinin Deðerlendirilmesi

Ibrahim Cagri Turker, Saniye Uke Uzun, Ceylan Uslu Dogan, Burcu Dirim, Emine Betul Akbas Ozyurek, Sumeyra Keles Yesiltas, Dilek Guven
Saðlýk Bilimleri Üniversitesi, Þiþli Hamidiye Etfal Eðitim ve Araþtýrma Hastanesi, Göz Hastalýklarý Anabilim Dalý, Ýstanbul

Amaç: Yüzeyel optik disk druseni (ODD) olan eriþkin hastalar ile saðlýklý eriþkinler arasýnda, optik koherens tomografi anjiyografi (OKT-A) ile deðerlendirilen peripapiller ve makuler vasküler akým deðiþikliklerini karþýlaþtýrmak.
Gereç ve Yöntemler: Bu retrospektif çalýþmaya nörooftalmoloji birimimizde takip edilen 22 yüzeyel ODD hastasýnýn 44 gözü ve rutin oftalmolojik muayene için kliniðimize baþvuran 27 saðlýklý bireyin 54 gözü dahil edildi. Üst, alt, nazal ve temporal radyal peripapiller kapiller pleksus (RPK) damar yoðunluðu (DY) deðerleri; üst, alt, nazal ve temporal parafoveal ve foveal bölge yüzeyel kapiller pleksus (YKP) ve derin kapiller pleksus (DKP) DY deðerleri; koryokapillaris akým alaný ve foveal avasküler zon (FAZ) alaný OKT-A ile deðerlendirildi.
Bulgular: Gruplar arasýnda yaþ ve cinsiyet açýsýndan istatistiksel olarak anlamlý fark yoktu. ODD'li olgularda temporal RPK DY deðerlerinde anlamlý bir azalma olurken (p = 0.02), diðer kadranlarda anlamlý bir fark saptanmadý. Gruplar arasýnda parafoveal bölge 4 kadran, foveal YKP ve DKP DY deðerlerinde veya foveal avasküler zon ölçümlerinde anlamlý farklýlýk bulunmazken, koryokapillaris akým alaný deðerleri çalýþma grubunda anlamlý olarak yüksekti (p = 0,012).
Sonuçlar: Sonuçlarýmýz, yüzeyel ODD'li olgularda RPK temporal kadran DY deðerlerinde azalma ve koryokapillaris akým alanýnda artýþ olduðunu gösterdi. ODD'nin optik sinir baþý ve makula perfüzyonu üzerindeki etkilerini deðerlendirmek ve altta yatan mekanizmalarý ve ikincil komplikasyonlarý anlamak için daha geniþ vaka serileri ile daha uzun takip süreli çalýþmalara ihtiyaç vardýr. (SETB-2021-05-139)

Anahtar Kelimeler: optik disk druseni, optik koherens tomografi anjiyografi, makuler vasküler akým, peripapiller vasküler akým, retina, nörooftalmoloji.

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