Nosocomial infection in the neonatal intensive care unit

B�lb�l, Ali; Ta�demir, Mehmet; Pullu, Mine; Okan, F�sun; B�lb�l, Lida; Nuho�lu, Asiye

Volume : 43 Issue : 1 Year : 2024

58/4Current Issue Accepted Articles Archive Covers Most Accessed Articles

Author Contribution Form

ICMJE COI Form

Nosocomial infection in the neonatal intensive care unit [Med Bull Sisli Etfal Hosp]

Med Bull Sisli Etfal Hosp. 2009; 43(1): 27-32

Nosocomial infection in the neonatal intensive care unit

Ali B�lb�l¹, Mehmet Ta�demir¹, Mine Pullu¹, F�sun Okan¹, Lida B�lb�l², Asiye Nuho�lu¹
¹Department of Neonatology, �i�li Etfal Training and Research Hospital, Istanbul,Turkey
²Department of Pediatrics, Bak�rk�y Dr. Sadi Konuk Training and Research Hospital, Istanbul,Turkey

Objective: The aim of this study was to evaluate the prevalence of nosocomial infection, distrubition and antibiotic resistance patterns of pathogen organisms in NICU (Neonatal Intensive Care Unit).
Study Design: This prospective study included all neonates hospitalized in NICU for one year period. The nosocomial infection was defined as hemoculture positivity after 72 hours of hospitalization or NOSEP (Nosocomial Sepsis Prediction for Newborns) score ≥11. The antibiotic resistance of identified microorganisms were recorded.
Results: In 1 year period, 1094 neonates were hospitalized. Of the 793 neonates, 675 blood cultures and 138 cultures from the other sites were collected. In 50 patients 62 hemoculture positivity were found among total hemocultures collected. Hundred and twenty four patients clinically thought to have nosocomial infection was evaluated for NOSEP criteria. In 26 neonates NOSEP score was found to be ≥11. In 138 cultures collected from the sites other than blood, 46 cultures were positive and 30 of them were accepted as nosocomial infection. According to the study criteria, 56 patients were found to have nosocomial infection. Nosocomial infection, ventilator and catheter associated nosocomial infection incidence were found to be 5.1 infection/1000 days, 1.8/1000 days and 1.6/1000 days respectively. Gram positive, gram negative bacteria and fungus were identified in 61.9%, 30.9% and 7.2% of cases respectively. The most common resistance pattern was meticilline resistance (55%) in coagulase negative staphylococci.
Conclusions: The most common pathogenic agents and the most common focus of infection were gram positive bacteria and conjunctivitis respectively. The low antibiotic resistance pattern of identified microorganisms was thought to be due to the restricted use of wide spectrum antibiotics in our unit.

Keywords: Nosocomial infection, newborn, coagulase negative staphylococcus, NOSEP

Yenido�an yo�un bak�m birimindeki hastane enfeksiyonlar�

Ali B�lb�l¹, Mehmet Ta�demir¹, Mine Pullu¹, F�sun Okan¹, Lida B�lb�l², Asiye Nuho�lu¹
¹�i�li Etfal E�itim ve Ara�t�rma Hastanesi, Yenido�an Klini�i, �stanbul
²Bak�rk�y Dr. Sadi Konuk E�itim ve Ara�t�rma Hastanesi, �ocuk Klini�i, �stanbul

Ama�: Yenido�an yo�un bak�m biriminde (YYBB) g�r�len hastane enfeksiyonu (HE) prevalans�n�n, etken da��l�m�n�n ve antibiyotik direncinin belirlenmesi ama�land�.
Gere� ve Y�ntem: YYBB�de 1 y�ll�k s�re i�erisinde, prospektif olarak yatan t�m hastalar �al��maya al�nd�. Hastane enfeksiyonu olarak; yat��ndan 72 saat sonra al�nan k�lt�rde �reme olmas� veya NOSEP (Nosocomial Sepsis Prediction for Newborns) skorunun ≥11 olmas� kabul edildi. �retilen patojenlerin antibiyotik diren�leri kaydedildi.
Bulgular: Bir y�ll�k s�re i�erisinde 1094 bebek yat�r�ld�. Belirlenen s�rede 793 bebekten, 675 kan k�lt�r� ve 138 di�er b�lge k�lt�r� topland�. Al�nan t�m kan k�lt�rlerinde 50 vakada 62 �reme saptand�. Klinik olarak hastane enfeksiyonu d��n�len 124 vaka NOSEP kriterleri a��s�ndan de�erlendirildi. NOSEP puanlamas� ≥11 olan 26 vaka saptand�. Di�er b�lgelerden al�nan 138 k�lt�r�n 46�s�nda �reme saptan�rken, HE kabul edilen k�lt�r say�s� 30 idi. �al��ma kriterlerine g�re 56 hastada HE tan�s� kondu. HE insidans� 5.1 enf /1000 g�n, ventilat�r ili�kili HE insidans�: 1.8/1000 g�n ve kateter ili�kili HE insidans� 1.6/1000 g�n bulundu. HE olarak saptanan etkenlerin da��l�m� %61.9 gram pozitif bakteri, %30.9 gram negatif bakteri ve %7.2 mantar �eklindeydi. En s�k saptanan diren� geli�imi koag�laz negatif stafilokoklarda %55 oran�nda metisiline diren� idi.
Sonu�lar: HE etkeni olarak en s�k gram pozitif bakteriler ve enfeksiyon oda�� olarak en s�k konjonktivit saptand�. �retilen mikroorganizmalarda antibiyotik direncinin az olmas�n�n, �nitemizde geni� spektrumlu antibiyotiklerin k�s�tl� kullan�lmas�na ba�l� oldu�u d��n�ld�.

Anahtar Kelimeler: Hastane enfeksiyonu, Yenido�an, Koag�laz negatif Stafilokok, NOSEP

Corresponding Author: Ali B�lb�l, T�rkiye
Manuscript Language: Turkish

CITE

Full Text PDF Download citation RIS EndNote BibTex Medlars Procite Reference Manager Send email to author Similar articles PubMed Google Scholar