The Effect of Hemodialysis on Levels of Endothelin-1 in Cases With Chronic Renal Failure

OBJECTIVE: This study is planned to investigate the effect of hemodialysis on levels ol Endothelin-1 (ET-1) in cases with chronic renal failure.
STUDY DESIGN: 20 patients who have chronic renalfailure were included to our study. 10 of them (Group A) were treated with hemodialysis, 10 of them (Grup B) weren' t. As for the control group 10 healty people selected. The levels of plasma ET-1 determined with the method ol radio immun assay (RIA).
RESULTS: The levels of plasma ET-1 was significantly higher patients who have chronic renal failure than healty people (p<0.001 ), but no significant changes was frýurýd between Group A and Group B (p>0.05).
CONCLUSION: These results suggested that hemodialysis has no effects on the levels of plasma ET -1. Also no significant changes was found between patients who have high blood pressure and normal blood pressure on the levels of plasma ET -1. This study also suggested that only uremia may he the cause of high levels of plasma ET-.

Kronik Renal Yetersizlikli Hastalarda Hemodiyalizin Plazma Endotilin-1 Düzeyi Üzerine Etkisi

AMAÇ: Bu çalýşma, kronik renal yetersizlikli hastalarda hemodiyalizin plazma endotelin-1 düzeyi üzerine olan etkisini araştýrmak amacýyla planlandý.
MATERYAL VE METOD: Çalýşmamýzda, 10 diyalize girmeyen (Grup A) ve 10 diyalize giren (Grup B) toplam 20 kronik renal yetersizlikti hasta alýndý. Kontrol grubu olarak 10 saðlýklý kişi seçildi. Bu hastalarda Radyo immun assay (RIA) metodu ile plazma endotelin-1 (ET-1) düzeylerine bakýldý.
BULGULAR: Kronik renal yetersizli hastalarýn tümünde plazma ET-1 düzeyleri normal grubu göre anlamlý derece- de yüksek hulundu (p<0.001 ). Grup A ve grup B arasýnda ise plazma ET-1 düzeylerinde anlamlý fark saptanmadý (p>0.05).
SONUÇ: Yapýlan çalýşmada, hemodiyalizin plazma ET-1 düzeyleri üzerinde etkili olmadýðý gösterilmiştir. Ayrýca, kan hasýncý normal ve yüksek olan hastalarda da plazma ET -1 düzeylerinde anlamlý bir fark saptanmamýş, bu da üreminin tek haşýna plazma ET-1 yüksekliğine neden olabileceðini düşündürmüştür.