ISSN : 1302-7123 | E-ISSN : 1308-5123
The Medical Bulletin of Sisli Etfal Hospital - Med Bull Sisli Etfal Hosp: 60 (1)
Volume: 60  Issue: 1 - 2026
FULL ISSUE
1. Full Issue

Pages I - X

REVIEW ARTICLE
2. The Role of Bedside Ultrasonography in Neonatal Central Venous Access Applications
Adil Umut Zubarioglu, Ali Bulbul, Hasan Sinan Uslu
doi: 10.14744/SEMB.2025.04206  Pages 1 - 8
Vascular access in critically ill neonates is crucial for management and is often challenging. Neonatal venous access must allow for the administration of all necessary medications and diagnostic tests. For these purposes, the catheter must be centrally located. Therefore, determining the correct location of the tip of central venous access devices is crucial, and traditionally, this assessment has relied on thoracoabdominal radiography. However, this method has limitations; it is an indirect method that uses radiological landmarks, is postprocedural, can only be used for tip location, and has long-term risks because of ionizing radiation. Current guidelines recommend that the imaging method used in central venous access procedures be real-time, intraprocedural, rapid, accurate, easy to use, noninvasive, reproducible, and inexpensive. Bedside ultrasonography, which possesses all these features, is considered the ideal imaging method. Ultrasonography is used with various catheter types for selecting the appropriate vein for catheterization, during needle insertion, for advancing the catheter in the correct direction, for catheter tip navigation, for determining catheter tip position, for monitoring puncture-site-related complications, and for identifying and monitoring late complications. The goal of this review was to examine the advantages and feasibility of using bedside ultrasonography in central venous catheter insertion procedures, especially in the newborn period.

ORIGINAL RESEARCH
3. Perspectives of Surgical Branch Residents on Anatomy Education and Its Importance
Zekiye Karaca Bozdag, Ayla Kurkcuoglu, Didem Daymaz Yilmaz, Nazire Kilic Safak, Buse Naz Candir Gurses
doi: 10.14744/SEMB.2026.52822  Pages 9 - 15
Objectives: To evaluate the pre-graduation anatomy training of residents from multiple surgical specialties and to assess their views and needs concerning anatomy during their surgical residency training.
Methods: Following the acquisition of the requisite institutional approvals, a questionnaire prepared using the Google Survey platform was circulated online among physicians at various stages of surgical residency training. This multicenter study included participants from multiple hospitals across different cities in Türkiye. Questions about participants' demographic characteristics and experiences with anatomy training during both their undergraduate and specialist training were asked. All responses were analyzed statistically.
Results: A total of 143 surgical residents participated in the study. Of the participants, 31.5% were female and 68.5% were male, and the mean age was 28±2.8 years. Of the residents, 67.1% had taken anatomy courses in the first two semesters of medical school, and 67.7% stated that they found their medical education inadequate for surgical residency. During their undergraduate education, 97.2% of the participants received face-to-face anatomy practice training, 47.6% received training with cadavers and plastic models. In addition, those who were trained with cadavers were more supportive of anatomy integration (p=0.031). It was also noteworthy that senior residents (defined as those with ≥2 years of residency training) considered anatomy integration into surgical residency training more necessary (p=0.006).
Conclusion: This study highlights the critical role of anatomy knowledge in surgical training and emphasizes its importance in the effective integration of education during surgical residency training.

4. Evaluation of Sexual Dysfunctions in Male Patients with Androgenetic Alopecia
Osman Vural, Ilknur Kivanc Altunay, Asli Aksu
doi: 10.14744/SEMB.2026.66915  Pages 16 - 23
Objectives: Androgenetic alopecia (AGA) is a common dermatologic condition among men. In this study, we aimed to investigate psychological comorbidities, sexual dysfunctions, and the relationship between them in male patients with AGA.
Methods: A total of 220 individuals aged between 18 and 45 years who applied to our dermatology outpatient clinic between June 2022 and June 2023 were included in this study, including 110 healthy male volunteers and 110 male patients diagnosed with AGA. To collect information about the individuals comprising the sample, a sociodemographic characteristics form prepared by the researcher, the Hospital Anxiety and Depression Scale (HADS), the Body Perception Scale (BPS), the Golombok–Rust Inventory of Sexual Satisfaction (GRISS), and the Sexual Health Inventory for Men (SHIM) were completed by the participants under the supervision of the researcher. The severity of AGA was determined using the Hamilton–Norwood Scale (HNS).
Results: In our study, it was found that the patient group was statistically significantly more negatively affected in terms of body satisfaction and had higher levels of anxiety, depression, and sexual dysfunction compared with the control group (p=0.028, p=0.001, p=0.001, respectively). It was found that impotence and the tendency to avoid sexual intercourse increased as anxiety symptoms increased in patients with AGA (p=0.010, r=0.245; p=0.006, r=0.259, respectively). Furthermore, an increase in depressive symptoms in patients with AGA was shown to increase the tendency toward erectile dysfunction and premature ejaculation (p=0.027, r=-0.210; p=0.001, r=0.366, respectively).
Conclusion: Physicians should take into account that AGA may trigger anxiety, depression, decreased body satisfaction, and sexual dysfunction in male patients, and patients should be evaluated in a multidisciplinary manner. While our study sheds light on future research, larger sample studies are needed to clarify these relationships.

5. The Relationship Between Neutrophil/Lymphocyte Ratio and the Progression and Clinical Features of Alzheimer's Disease
Hatice Omercikoglu Ozden, Fatma Seyda Ustuner, Merve Bikem Ucar, Fatma Nazli Durmaz Celik
doi: 10.14744/SEMB.2026.67764  Pages 24 - 29
Objectives: This study aimed to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR), a peripheral inflammatory marker, and both baseline clinical features and short-term cognitive progression in patients with Alzheimer’s disease (AD). Specifically, we sought to determine whether NLR is associated with disease stage, cognitive performance, vascular comorbidities, and 12-month cognitive decline assessed by the Mini-Mental State Examination (MMSE).
Methods: We conducted a retrospective observational study including 100 adults diagnosed with mild, moderate, or severe AD who were followed for at least 12 months at a tertiary memory clinic. Demographic characteristics, clinical data, and serial MMSE scores (baseline, 6 months, and 12 months) were extracted from medical records. Complete blood counts from the same time points were used to calculate NLR. Descriptive statistics summarized clinical variables. Correlations between NLR and MMSE scores were analyzed using Pearson and Spearman methods. Group comparisons across disease stage, sex, and vascular comorbidity were performed using t-tests or ANOVA as appropriate. Statistical significance was defined as p<0.05.
Results: The mean age of the cohort was 72.5±9.9 years, and 62% were women. Baseline disease severity was distributed as mild (28%), moderate (26%), and severe (46%). Mean baseline NLR was 2.41±1.17, increasing to 2.87±1.47 at 6 months and 3.75±3.54 at 12 months. Baseline NLR was significantly higher in patients with vascular comorbidities (p=0.008) but did not differ across AD severity categories. Higher baseline NLR was modestly associated with lower baseline MMSE scores (r=−0.24, p=0.021). Unexpectedly, higher baseline NLR correlated with a smaller decline in MMSE over 12 months (r=0.36, p=0.005). Patients with low NLR showed greater cognitive deterioration (−3.72±3.97 points) than those with high NLR (−1.38±4.38 points; p=0.037).
Conclusion: NLR was associated with worse cognitive performance at diagnosis and increased gradually over 12 months in AD patients, supporting its role as a marker of systemic inflammation. However, the counterintuitive finding that higher baseline NLR was linked to slower short-term cognitive decline highlights the complexity of inflammatory mechanisms in established AD. These results suggest that while NLR reflects clinically relevant inflammatory status, it should not be used as a standalone predictor of disease progression but rather as part of a broader multimodal biomarker framework.

6. Comparison of the Therapeutic Effects of Intra-Articular Injection of Ozone and Corticosteroid in Knee Osteoarthritis
Aylin Ayyildiz, Selda Ciftci Inceoglu, Beril Dogu, Banu Kuran
doi: 10.14744/SEMB.2025.52460  Pages 30 - 35
Objectives: Knee osteoarthritis (KOA) is a chronic condition that gradually reduces functional capacity and limits daily activities. Treatment methods in the early stages of the disease are still under discussion. The efficacy of ozone therapy versus corticosteroid injection in treating KOA is examined in this study.
Methods: This randomized clinical trial involved 60 patients aged 40-85 years who had been experiencing knee pain for at least 6 months and had received a clinical diagnosis of knee osteoarthritis through radiologic imaging. The patients were randomly assigned to two groups. One group received an intra-articular injection of 10 mL 15 µg/ml ozone for three sessions with a one-week interval, while the second group received a 1 mL intra-articular injection of betamethasone. All patients were evaluated before treatment, as well as 4 and 12 weeks after the first dose of treatment. The study evaluated treatment efficacy using the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC).
Results: The study participants had a mean age of 62.2±10 years, and 90% of them were female. Upon comparing the VAS and WOMAC scores with their respective pretreatment scores, both groups showed significant decreases at week 4 and week 12. Nota-bly, the ozone group exhibited a significantly greater improvement in VAS and WOMAC scores at week 4.
Conclusion: Intra-articular ozone injections have a rapid effect and provide better short-term results for KOA. In later periods, it has a similar effect to corticosteroids.

7. A Novel Marker in Hypogonadal Hypogonadism: Apelin
Alperen Akansel Caglar, Engin Sebin, Emine Kartal Baykan, Ayse Carlioglu
doi: 10.14744/SEMB.2025.92160  Pages 36 - 42
Objectives: Apelin is a recently identified adipokine with pleiotropic actions in cardiovascular regulation, metabolic homeostasis, bone remodeling, and reproductive physiology. Through binding to the apelin receptor (APJ), apelin has been shown to influence gonadotropin-releasing hormone (GnRH) secretion, which is essential for the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Given its potential role in the hypothalamic–pituitary–gonadal (HPG) axis, alterations in circulating apelin may contribute to hypogonadotropic hypogonadism (HH). This study aimed to investigate whether serum apelin concen-trations are altered in patients with HH and to evaluate its potential relevance as a complementary biomarker in the diagnostic approach to HH.
Methods: A total of 60 participants were enrolled: 30 newly diagnosed HH patients (untreated for at least one year, with no comorbid chronic diseases) and 30 age- and body mass index (BMI)-matched healthy controls. Individuals with BMI<20 or BMI>30 were excluded to minimize confounding metabolic influences on apelin secretion. Following overnight fasting, venous blood samples were obtained for complete biochemical and hormonal profiles. Serum apelin levels were measured using a validated human ELISA kit (SunRed Biotechnology, China; intra- and inter-assay coefficients of variation<10%). Statistical analysis was performed using SPSS 17.0.
Results: Apelin concentrations were significantly lower in HH patients compared with healthy controls (median 35.2ng/L vs. 63.3ng/L, p=0.046). ROC analysis yielded an area under the curve (AUC) of 0.65, with a sensitivity of 76% and a specificity of 64%.
Conclusion: These findings demonstrate reduced circulating apelin concentrations in HH, supporting the hypothesis of its involvement in GnRH regulation and the pathogenesis of hypogonadism. Although its diagnostic accuracy is modest, apelin may complement traditional hormonal markers. Further multicenter studies and mechanistic research are required to validate these observations.

8. Evaluation of Postoperative Cognitive Dysfunction and Its Risk Factors in Elderly Patients Undergoing Elective Non-Cardiac Surgery: A Prospective Observational Study
Arzu Ceren Yigit, Tugba Yucel Yenice, Mustafa Altinay, Ayse Surhan Cinar, Leyla Turkoglu Kilinc
doi: 10.14744/SEMB.2025.47700  Pages 43 - 52
Objectives: This study aimed to evaluate the incidence, course, and potential risk factors of postoperative cognitive dysfunction (POCD) in elderly patients undergoing elective non-cardiac surgery.
Methods: A prospective observational study was conducted on 35 patients aged 60 years and older who underwent elective non-cardiac surgery under general or regional anesthesia. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) test preoperatively, at 24 hours, and on postoperative day 30. Demographic characteristics, comorbidities, perioperative events, and anesthesia-related factors were recorded.
Results: The mean preoperative MoCA score was 20.9±3.2, which decreased significantly to 18.0±2.6 at 24 hours (p<0.001) and improved to 22.7±2.7 by postoperative day 30 (p<0.001). The incidence of cognitive dysfunction (MoCA <21) was 42.9% preoperatively, 85.7% at 24 hours, and 20.0% at day 30. No significant associations were found between POCD and comorbidities, anesthesia type, intraoperative hypotension, bleeding, transfusion, or narcotic use (p>0.05). However, preoperative cognitive performance was lower among patients with lower education levels, and postoperative day-30 scores were significantly lower among smokers (p=0.043).
Conclusion: POCD was common in the early postoperative period but largely resolved by day 30. Smoking and low educational level were associated with poorer cognitive outcomes. Larger multicenter studies are needed to further clarify risk factors and long-term neurocognitive trajectories in elderly surgical patients.

9. Measles Seroprevalence and Associated Factors among Adult Individuals in the City Center of Şanlıurfa Province
Ahmet Gunduzalp, Burcu Beyazgul, Feyyaz Barlas
doi: 10.14744/SEMB.2025.88655  Pages 53 - 61
Objectives: The aim is to determine measles seroprevalence in adult individuals in Şanlıurfa city center and to evaluate related factors.
Methods: The research is of a cross-sectional type. The research was carried out in Şanlıurfa city center between March 2023 and April 2023. The population of the study consisted of individuals over the age of 18 who applied to the Family Health Centers (FHC) in the city center of Şanlıurfa. A 30-cluster sampling method was used to determine the FHCs where the study would be conducted. In this study, the number of people to be included in each cluster was determined as 7, and the total sample size was 210. Thirty FHCs were randomly selected from a total of 80 ASMs in 3 central districts in Şanlıurfa, proportional to the number of units. Blood was drawn from the participants by the researcher. The blood samples were then sent by a private hospital to a private laboratory for testing.
Results: A total of 210 adults were included in the study. Fifty-one percent of the participants were women. The measles seropositivity rate of the adults participating in the study was 87.6%, and the measles seronegativity rate was 8.6%. When the participants were examined according to age groups, it was found that the measles seropositivity level was lowest in the 18-21 age group, at 52.63%. In the created logistic regression model, measles seropositivity status in adults: being 33 years or younger reduces it 10 times.
Conclusion: This study showed that measles seropositivity in the adult population in Şanlıurfa city center was 87.6%. This suggests the need to reconsider the administration of an extra-dose measles vaccine using the catch-up vaccination method for individuals aged 18-21 and then 22-25, the most susceptible age group in this study.

10. Fatty Liver and Pancreatic Steatosis in Patients with Chronic Hepatitis B and C and Wilson's Disease
Mehmet Aksoy, Feyza Gelebek, Kemal Ozan Lule, Nezihe Otay Lule, Abdullah Emre Yildirim, Sezgin Barutcu
doi: 10.14744/SEMB.2025.79735  Pages 62 - 70
Objectives: The aim of this study is to determine the presence of fatty liver and pancreatic steatosis in individuals diagnosed with Chronic Hepatitis B (CHB), Chronic Hepatitis C (CHC), and Wilson's Disease (WD) and to evaluate the relationship between the presence of fatty liver and pancreatic steatosis and laboratory parameters.
Methods: Forty-eight CHB, fifty-six CHC, and thirty-five WD patients were included in the study. Pancreatic steatosis was measured by three methods: steatosis according to the mean pancreas value, steatosis according to the pancreas/spleen difference value, and steatosis according to the pancreas/spleen density ratio. Hepatic steatosis was measured by noncontrast CT using multi-site attenuation sampling and the Liver Attenuation Index (LAI); steatosis was graded according to predefined LAI cut-offs. Fatty liver and pancreatic steatosis were graded as Grade 1, 2, or 3. Certain laboratory parameters of the patients were also retrospectively reviewed.
Results: In 69.1% of all patients, grade 1 fatty liver disease was present. Pancreatic steatosis was absent in 50.3% of patients ac-cording to the mean pancreas value, 63.3% according to the pancreas/spleen difference, and 61.9% according to the pancreas/spleen density ratio. Fatty liver disease was positively correlated with high Erythrocyte Sedimentation Rate (ESR) (r=0.255, p=0.002) and Alanine Transaminase (ALT) (r=0.180, p=0.034). ESR (p=0.025) and urea level (p=0.024) were found to be significantly higher in the group with steatosis according to the mean pancreas value. According to the group with steatosis based on the pancreas/spleen density ratio, globulin level was significantly higher (p=0.038). The rates of steatosis according to the pancreas mean value (p=0.003) and the pancreas/spleen density ratio (p=0.039) were significantly more advanced in CHC patients compared with the other patient groups. There was no statistically significant difference between the stage of fatty liver and the stage of fatty pancreas (p>0.05).
Conclusion: Although fatty liver and pancreatic steatosis are considered similar pathologies, our findings suggest that these two conditions should not be considered interchangeable. Further studies with larger samples may be useful to better demonstrate the correlation between the two conditions and the investigated parameters.

11. Approaches to Mediastinal Staging in NSCLC Among Thoracic Surgeons: A Survey Study From Türkiye
Melike Ulker, Volkan Erdogu, Ali Cevat Kutluk, Muzaffer Metin
doi: 10.14744/SEMB.2025.04903  Pages 71 - 78
Objectives: Mediastinal lymph node staging is a critical step in the treatment algorithm for non-small cell lung cancer (NSCLC). Current guidelines define the patient groups in which invasive or minimally invasive mediastinal lymph node sampling is required during preoperative staging. This study aimed to determine the extent to which thoracic surgeons actively practicing in Türkiye adhere to these guideline recommendations and to assess the concordance between their daily clinical practices and these recommendations.
Methods: A guideline-based survey, including nine case scenarios, was emailed to 417 thoracic surgeons registered with the Turkish Thoracic Surgery Association. The survey collected data on participants’ demographic characteristics, institutional profiles, and approaches to each clinical scenario. Responses were analyzed for concordance with guideline recommendations.
Results: The survey response rate was 29.2% (n=122). A total of 48.3% of the participants possessed an academic title, and 77.8% were employed at training and research or university hospitals. In scenarios involving a radiologically positive, single, non-bulky N2 lymph node, 85.2% of respondents indicated that invasive mediastinal staging was required by guidelines. In contrast, among patients without radiologic evidence of N2 disease, the proportion of surgeons recommending mediastinal staging was 19.7% for squamous cell carcinoma >3 cm in size and 36.9% for adenocarcinoma. For centrally located tumors, 59% of participants recommended staging. Notably, there was substantial variation in opinions regarding the necessity of invasive sampling for suspicious aortopulmonary window lymph nodes.
Conclusion: Thoracic surgeons in Türkiye generally exhibit approaches to mediastinal staging that align with guideline recommendations; however, variations exist in certain subgroups. Standardization is particularly needed in the definition of central tumors, the approach to sampling aortopulmonary lymph node stations, and staging strategies based on histologic tumor type. These findings highlight the importance of educational and awareness initiatives aimed at improving the integration of guideline recommendations into clinical practice.

12. The Effect of Systemic Steroid Use on the Success of Core Decompression in Non-Traumatic Early-Stage Femoral Head Osteonecrosis
Gokhan Pehlivanoglu, Osman Cimen, Alper Koksal
doi: 10.14744/SEMB.2025.04207  Pages 79 - 84
Objectives: Systemic corticosteroid use is a well-established risk factor for non-traumatic osteonecrosis of the femoral head (ONFH). However, its impact on the clinical outcomes of joint-preserving procedures, such as core decompression (CD), remains uncertain. This study aimed to evaluate whether systemic steroid exposure influences the success of CD in patients with early-stage ONFH.
Methods: This retrospective cohort study included 49 hips from 41 patients with Ficat stage IIa ONFH who underwent isolated CD between 2013 and 2021. Patients were stratified into two groups according to systemic corticosteroid use within one year prior to diagnosis. Demographic and radiologic data, including modified Kerboul angle and stage, were collected. Treatment success was defined as the absence of femoral head collapse or conversion to total hip arthroplasty at the final radiologic follow-up. Outcomes were compared between steroid users and non-users using t-tests, Mann–Whitney U, chi-square, and Fisher’s exact tests, as appropriate.
Results: Overall, treatment success was achieved in 63.3% of hips. The success rate was 70.4% in steroid users and 54.5% in non-users, but this difference was not statistically significant (p=0.372). Baseline radiologic parameters, including modified Kerboul angle and stage, did not differ significantly. Sex distribution differed significantly (p=0.003), while age, follow-up duration, and bilaterality were comparable.
Conclusion: Systemic corticosteroid use was not significantly associated with worse radiologic outcomes following CD in early-stage ONFH. These findings support CD as a viable joint-preserving treatment in appropriately selected patients, irrespective of prior steroid exposure.

13. Interscalene Block versus Posterior Suprascapular Block for Postoperative Analgesia on Arthroscopic Shoulder Surgery: Randomized, Controlled, Prospective Study
Sinem Ozler, Leyla Kilinc, Gamze Dilara Demir, Tugba Yucel, Pinar Sayin, Ayse Surhan Cinar
doi: 10.14744/SEMB.2026.65391  Pages 85 - 92
Objectives: This study aimed to compare the effects of interscalene block and posterior suprascapular nerve block on postoperative analgesia in the first 24 hours after unilateral arthroscopic shoulder surgery.
Methods: Ninety-eight adult patients aged between 18 and 65 years, with ASA (American Society of Anesthesiologists) physical status I–II, undergoing elective arthroscopic shoulder surgery were included in this prospective, randomized controlled study. All patients were randomized into two groups: the interscalene block group (Group ISB, n=48) and the suprascapular block group (Group SSB, n=50). Both groups received 10 mL of 0.5% bupivacaine. The duration of analgesia, total opioid consumption, compli-cations, and Visual Analog Scale (VAS) scores were recorded at postoperative 0, 1, 4, 6, 12, and 24 hours.
Results: Statistical data were analyzed in 87 patients after 7 patients from Group SSNB and 4 patients from Group ISB were excluded from the study. There was no significant difference between the two groups in analgesia duration, total opioid consumption, and patient satisfaction. While VAS values at 0 hours (p<0.01), 1 hour (p<0.05), 4 hours (p<0.01), and 6 hours (p<0.01) were lower in Group ISB, the VAS value at the 12th hour was similar between Group SSB and Group ISB (p>0.05). However, the VAS value at the 24th hour was lower in Group SSB (p<0.01). The complication rate was higher in Group ISB (p<0.01).
Conclusion: It was concluded that ultrasound-guided posterior SSB for postoperative pain after arthroscopic shoulder surgery is not equivalent to ISB, especially in the early postoperative period, but it is an effective alternative technique with fewer side effects.

14. Validation of the Turkish Version of the Quality of Recovery-15 Questionnaire
Kaan Sunter, Kadir Yagiz Turker, Can Ates, Mehmet Ali Koc, Yusuf Sevim, Cemal Ensari, Onur Ilkay Dincer, Ismail Cem Eray, Burak Yavuz, Timucin Erol, Siyar Ersoz, Burak Kutlu, Mehmet Ayhan Kuzu
doi: 10.14744/SEMB.2026.70933  Pages 93 - 102
Objectives: The aim of this study was to perform a cross-cultural adaptation and psychometric evaluation of the Quality of Recovery-15 (QoR-15) questionnaire in Türkiye.
Methods: The QoR-15 was translated into Turkish through a rigorous process involving independent translations, consensus, forward–backward translation, and review. The questionnaire was administered to patients undergoing major abdominal surgery preoperatively and on postoperative days 1, 7, and 30. Reliability was assessed using Cronbach's α, McDonald’s Omega, and the inter-item correlation coefficient. Construct validity was evaluated using confirmatory factor analysis (CFA), and responsiveness was analyzed using Cohen's effect size and the standardized response mean (SRM).
Results: A total of 510 patients participated in the study; 335 (65.69%) were <65 years old, and 279 (54.71%) were male. The Turkish version of QoR-15 (QoR-15T) demonstrated good internal consistency, with Cronbach's α values of 0.896 and 0.888 for preoperative and postoperative administrations, respectively, and McDonald’s Omega coefficients of 0.894 and 0.878. Confirmatory factor analysis confirmed the two-factor (two-dimensional) structure of the QoR-15T. The comparative fit indices for Models 1 and 2 were 0.970 and 0.991, respectively. QoR-15T showed responsiveness to changes in health status, with Cohen's effect size (1.22) and the standardized response mean (1.18) indicating its ability to detect clinically important changes.
Conclusion: The QoR-15T is a reliable, valid, and responsive questionnaire for assessing the quality of recovery in patients undergoing major abdominal surgery. Its ability to capture patients' perspectives and multidimensional aspects of recovery makes it a valuable tool for clinical and research purposes.

15. Clinical Characteristics and Pregnancy Outcomes of Thyrotoxicosis During Pregnancy: A Retrospective Observational Study
Ummu Mutlu, Ayse Merve Ok Kurt, Evin Bozkur
doi: 10.14744/SEMB.2026.88528  Pages 103 - 111
Objectives: Thyrotoxicosis during pregnancy may be associated with adverse maternal and foetal outcomes; however, data comparing overt and subclinical thyrotoxicosis are limited. This study aimed to evaluate clinical characteristics, management, and pregnancy outcomes, and to explore associations with the achievement of euthyroidism in pregnant women with thyrotoxicosis.
Methods: This retrospective study included 70 pregnant women diagnosed with thyrotoxicosis who presented to the outpatient clinics between 2022–2023. Patients were classified as having overt (n=34) or subclinical (n=36) thyrotoxicosis based on trimester-specific thyroid function tests. After excluding three patients with Graves’ disease and one with a molar pregnancy, 31 overt and 35 subclinical gestational thyrotoxicosis patients were included in the analyses. Demographic features, clinical findings, biochemical parameters standardized as multiples of the upper limit of normal, treatment data, and pregnancy outcomes were obtained from medical records. Correlation analyses were performed to evaluate associations between gestational week and thyroid function tests.
Results: The mean age was 29.6±5.3 years, and the mean GW at diagnosis was 10.7±3.0, with no significant differences between groups. At diagnosis, TSH was lower and fT4/fT3 higher in overt thyrotoxicosis compared to subclinical cases (p<0.05). Euthyroidism was achieved at a mean of 17.1±4.0 weeks, without significant group differences. Prior antithyroid drug therapy had been initi-ated in 18.2% of patients, mainly with PTU, with similar doses and treatment durations between groups. Pregnancy outcomes were available for 42 patients; 13 experienced complications (oligohydramnios, preterm delivery, pre-eclampsia, gestational diabetes, and intrauterine foetal death). Complication rates did not differ between groups, although anti-TPO positivity was more frequent among patients with complications (p=0.006). Correlation analyses showed that earlier gestational age at diagnosis was associ-ated with higher thyroid hormone levels, while later achievement of euthyroidism correlated with lower TSH and higher peak fT3. Conclusion: Pregnancy outcomes were similar in overt and subclinical thyrotoxicosis. Gestational age at diagnosis was associated with thyroid hormone levels but not with maternal or foetal complications. Most patients achieved euthyroidism during preg-nancy, and anti-TPO positivity was more common among those with pregnancy complications.

16. Evaluation of Liver Steatosis and Liver Fibrosis in Patients with Type 1 Diabetes Mellitus Using Non-invasive Scores
Zulal Istemihan, Fatih Bektas, Ali Emre Bardak, Cansu Kiziltas, Gamze Kemec, Ziya Imanov, Ibrahim Volkan Senkal, Kanan Nuriyev, Aynura Rustamzade, Sezen Genc Ulucecen, Hulya Hacisahinogullari, Kubilay Karsidag, Bilger Cavus, Asli Ciftbasi Ormeci, Filiz Akyuz, Kadir Demir, Fatih Besisik, Sabahattin Kaymakoglu
doi: 10.14744/SEMB.2026.57777  Pages 112 - 119
Objectives: This study aimed to investigate the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and clinically significant fibrosis (CSF) in patients with type 1 diabetes mellitus (T1DM), as well as the factors affecting them, using non-invasive tests based on blood and imaging methods.
Methods: Adult T1DM patients who were followed up in the diabetes mellitus outpatient clinic at a tertiary university hospital and who did not have other causes of liver disease were prospectively investigated. MASLD and CSF were evaluated using non-invasive scores based on biochemical tests and FibroScan®. MASLD was defined as a FibroScan® CAP score ≥275 dB/m, and CSF was defined as F≥8 kPa in the absence of any other chronic liver disease or secondary cause of hepatic steatosis in T1DM patients.
Results: The prevalence of MASLD and CSF was 12.9% and 5%, respectively. BMI, fasting blood glucose, and waist and hip circumference were significantly higher in patients with MASLD (p<0.05). The rates of hypertension and dyslipidemia were also higher in patients with MASLD (p=0.026 and p=0.012, respectively). According to Pearson’s correlation test, LSM was most strongly correlated with Agile 4 (p<0.001, r=0.922) and Agile 3+ scores (p<0.001, r=0.685). CAP was most strongly correlated with the fatty liver index (p<0.001, r=0.514) and the hepatic steatosis index (p<0.001, r=0.404).
Conclusion: Components of metabolic syndrome are important risk factors for MASLD in patients with T1DM. There is currently no consensus on screening and diagnostic pathways for MASLD in T1DM, and further research is needed in this area.

CASE REPORT
17. A Rare Cosmetic Lengthening Complication Causing Precice Stryde Nail Failure: A Case Report
Muharrem Kanar, Enver Ipek, Suleyman Cakirturk
doi: 10.14744/SEMB.2025.20586  Pages 120 - 123
Limb-lengthening surgeries have been described for medical and cosmetic treatment. Innovative surgical procedures and various instrumentation techniques have been developed with advancing technology. Remote-controlled intramedullary lengthening nail systems (RCILNS) are frequently used in limb-lengthening surgery. In the literature, few surgical complications have been reported in limb-lengthening surgery. Here, we present a case of an unexpected complication caused by a filling material previously applied for gluteal augmentation in a patient who underwent cosmetic limb-lengthening surgery.

18. Thoracoscopic Bronchovascular (Double) Sleeve Lobectomy to Correct Intraoperative Vascular Injury: A Case Report
Volkan Erdogu, Melike Ulker, Merve Ekinci Fidan, Ali Cevat Kutluk, Muzaffer Metin
doi: 10.14744/SEMB.2026.71463  Pages 124 - 129
Double sleeve lobectomy, involving both bronchial and vascular reconstruction, is a complex but lung-sparing alternative to pneumonectomy for centrally located tumors. While traditionally performed via thoracotomy, its application through video-assisted thoracoscopic surgery (VATS) remains limited. We report the first known case of a double sleeve lobectomy in Türkiye performed via a VATS approach in a 58-year-old female with a centrally located left upper lobe pleomorphic carcinoma involving both the pulmonary artery and bronchus. This case demonstrates the technical feasibility of VATS double-sleeve lobectomy when performed by experienced surgeons and shows that a mistake made during pulmonary artery division does not necessarily result in pneumonectomy.

LETTER TO THE EDITOR
19. Comment on ‘Risk Factors Influencing Recurrence Rates Following Open Excision of Wrist Ganglion Cysts: A Retrospective Cohort Study’
Kishankumar Mahida, Snehal Rajendra Jagtap
doi: 10.14744/SEMB.2026.47897  Pages 130 - 131
Abstract |Full Text PDF

LETTER TO THE EDITOR REPLY
20. Reply to Letter to the Editor ‘Comment on ‘Risk Factors Influencing Recurrence Rates Following Open Excision of Wrist Ganglion Cysts: A Retrospective Cohort Study’
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doi: 10.14744/SEMB.2026.02058  Page 132
Abstract |Full Text PDF

LETTER TO THE EDITOR
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doi: 10.14744/SEMB.2026.95695  Pages 133 - 134
Abstract |Full Text PDF

LETTER TO THE EDITOR REPLY
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Abstract |Full Text PDF

LETTER TO THE EDITOR
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Abstract |Full Text PDF

LETTER TO THE EDITOR REPLY
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Abstract |Full Text PDF

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